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000893764 1001_ $$0P:(DE-Juel1)176380$$aCamargo, Luana$$b0$$ufzj
000893764 245__ $$aPEAβ Triggers Cognitive Decline and Amyloid Burden in a Novel Mouse Model of Alzheimer’s Disease
000893764 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2021
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000893764 520__ $$aUnderstanding the physiopathology of Alzheimer’s disease (AD) has improved substantially based on studies of mouse models mimicking at least one aspect of the disease. Many transgenic lines have been established, leading to amyloidosis but lacking neurodegeneration. The aim of the current study was to generate a novel mouse model that develops neuritic plaques containing the aggressive pyroglutamate modified amyloid-β (pEAβ) species in the brain. The TAPS line was developed by intercrossing of the pEAβ-producing TBA2.1 mice with the plaque-developing line APPswe/PS1ΔE9. The phenotype of the new mouse line was characterized using immunostaining, and different cognitive and general behavioral tests. In comparison to the parental lines, TAPS animals developed an earlier onset of pathology and increased plaque load, including striatal pEAβ-positive neuritic plaques, and enhanced neuroinflammation. In addition to abnormalities in general behavior, locomotion, and exploratory behavior, TAPS mice displayed cognitive deficits in a variety of tests that were most pronounced in the fear conditioning paradigm and in spatial learning in comparison to the parental lines. In conclusion, the combination of a pEAβ- and a plaque-developing mouse model led to an accelerated amyloid pathology and cognitive decline in TAPS mice, qualifying this line as a novel amyloidosis model for future studies.
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000893764 7001_ $$0P:(DE-Juel1)131792$$aSchöneck, Michael$$b1$$ufzj
000893764 7001_ $$0P:(DE-HGF)0$$aSangarapillai, Nivethini$$b2
000893764 7001_ $$0P:(DE-Juel1)164541$$aHonold, Dominik$$b3$$ufzj
000893764 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b4$$ufzj
000893764 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b5
000893764 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b6
000893764 7001_ $$0P:(DE-Juel1)159137$$aKutzsche, Janine$$b7
000893764 7001_ $$0P:(DE-Juel1)165908$$aSchemmert, Sarah$$b8$$ufzj
000893764 7001_ $$0P:(DE-Juel1)144347$$aWilluweit, Antje$$b9$$eCorresponding author
000893764 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms22137062$$gVol. 22, no. 13, p. 7062 -$$n13$$p7062 -$$tInternational journal of molecular sciences$$v22$$x1422-0067$$y2021
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