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000893832 1001_ $$0P:(DE-Juel1)161350$$aDoppler, Christopher E J$$b0$$eCorresponding author$$ufzj
000893832 245__ $$aRegional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease
000893832 260__ $$aOxford$$bOxford Univ. Press$$c2021
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000893832 520__ $$aPrevious studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of noradrenergic terminal transporters.Combining these methods, we investigated the relationship of neurodegeneration in these distinct compartments in Parkinson’s disease. We examined 93 subjects (40 healthy controls and 53 Parkinson’s disease patients) with neuromelanin-sensitive turbo spin-echo MRI and calculated locus coeruleus-to-pons signal contrasts. Voxels with the highest intensities were extracted from published locus coeruleus coordinates transformed to individual MRI. To also investigate a potential spatial pattern of locus coeruleus degeneration, we extracted the highest signal intensities from the rostral, middle, and caudal third of the locus coeruleus. Additionally, a study-specific probabilistic map of the locus coeruleus was created and used to extract mean MRI contrast from the entire locus coeruleus and each rostro-caudal subdivision. Locus coeruleus volumes were measured using manual segmentations.
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000893832 7001_ $$0P:(DE-HGF)0$$aKinnerup, Martin B$$b1
000893832 7001_ $$0P:(DE-Juel1)184720$$aBrune, Corinna$$b2
000893832 7001_ $$0P:(DE-Juel1)138244$$aFarrher, Ezequiel$$b3$$ufzj
000893832 7001_ $$0P:(DE-HGF)0$$aBetts, Matthew$$b4
000893832 7001_ $$0P:(DE-HGF)0$$aFedorova, Tatyana D$$b5
000893832 7001_ $$0P:(DE-HGF)0$$aSchaldemose, Jeppe L$$b6
000893832 7001_ $$0P:(DE-HGF)0$$aKnudsen, Karoline$$b7
000893832 7001_ $$0P:(DE-HGF)0$$aIsmail, Rola$$b8
000893832 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline D$$b9$$ufzj
000893832 7001_ $$0P:(DE-HGF)0$$aHansen, Allan K$$b10
000893832 7001_ $$0P:(DE-HGF)0$$aStær, Kristian$$b11
000893832 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R$$b12$$ufzj
000893832 7001_ $$0P:(DE-HGF)0$$aBrooks, David J$$b13
000893832 7001_ $$0P:(DE-HGF)0$$aNahimi, Adjmal$$b14
000893832 7001_ $$0P:(DE-HGF)0$$aBorghammer, Per$$b15
000893832 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b16$$ufzj
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000893832 8564_ $$uhttps://juser.fz-juelich.de/record/893832/files/awab236.pdf
000893832 8564_ $$uhttps://juser.fz-juelich.de/record/893832/files/Doppler_2021_Brain_Regional%20locus%20coeruleus....pdf$$yPublished on 2021-07-01. Available in OpenAccess from 2022-07-01.
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