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@ARTICLE{Doppler:893832,
      author       = {Doppler, Christopher E J and Kinnerup, Martin B and Brune,
                      Corinna and Farrher, Ezequiel and Betts, Matthew and
                      Fedorova, Tatyana D and Schaldemose, Jeppe L and Knudsen,
                      Karoline and Ismail, Rola and Seger, Aline D and Hansen,
                      Allan K and Stær, Kristian and Fink, Gereon R and Brooks,
                      David J and Nahimi, Adjmal and Borghammer, Per and
                      Sommerauer, Michael},
      title        = {{R}egional locus coeruleus degeneration is uncoupled from
                      noradrenergic terminal loss in {P}arkinson’s disease},
      journal      = {Brain},
      volume       = {144},
      number       = {9},
      issn         = {1460-2156},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2021-02871},
      pages        = {2732–2744},
      year         = {2021},
      abstract     = {Previous studies have reported substantial involvement of
                      the noradrenergic system in Parkinson’s disease.
                      Neuromelanin-sensitive MRI sequences and PET tracers have
                      become available to visualize the cell bodies in the locus
                      coeruleus and the density of noradrenergic terminal
                      transporters.Combining these methods, we investigated the
                      relationship of neurodegeneration in these distinct
                      compartments in Parkinson’s disease. We examined 93
                      subjects (40 healthy controls and 53 Parkinson’s disease
                      patients) with neuromelanin-sensitive turbo spin-echo MRI
                      and calculated locus coeruleus-to-pons signal contrasts.
                      Voxels with the highest intensities were extracted from
                      published locus coeruleus coordinates transformed to
                      individual MRI. To also investigate a potential spatial
                      pattern of locus coeruleus degeneration, we extracted the
                      highest signal intensities from the rostral, middle, and
                      caudal third of the locus coeruleus. Additionally, a
                      study-specific probabilistic map of the locus coeruleus was
                      created and used to extract mean MRI contrast from the
                      entire locus coeruleus and each rostro-caudal subdivision.
                      Locus coeruleus volumes were measured using manual
                      segmentations.},
      cin          = {INM-3 / INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34196700},
      UT           = {WOS:000733722200033},
      doi          = {10.1093/brain/awab236},
      url          = {https://juser.fz-juelich.de/record/893832},
}