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@ARTICLE{Schnakenberg:893852,
      author       = {Schnakenberg, Patricia and Hahn, Lisa and Stickel, Susanne
                      and Stickeler, Elmar and Habel, Ute and Eickhoff, Simon B.
                      and Chechko, Natalia and Dukart, Juergen},
      title        = {{E}xamining early structural and functional brain
                      alterations in postpartum depression through multimodal
                      neuroimaging},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-02876},
      pages        = {13551},
      year         = {2021},
      abstract     = {Postpartum depression (PPD) affects approximately 1 in 10
                      women after childbirth. A thorough understanding of a
                      preexisting vulnerability to PPD will likely aid the early
                      detection and treatment of PPD. Using a within-sample
                      association, the study examined whether the brain's
                      structural and functional alterations predict the onset of
                      depression. 157 euthymic postpartum women were subjected to
                      a multimodal MRI scan within the first 6 days of childbirth
                      and were followed up for 12 weeks. Based on a clinical
                      interview 12 weeks postpartum, participants were classified
                      as mentally healthy or having either PPD or adjustment
                      disorder (AD). Voxel-based morphometry and resting-state
                      functional connectivity comparisons were performed between
                      the three groups. $13.4\%$ of women in our study developed
                      PPD (n = 21) and $12.1\%$ (n = 19) adjustment disorder (AD).
                      The risk factors for PPD were a psychiatric history and the
                      experience and severity of baby blues and the history of
                      premenstrual syndrome. Despite the different risk profiles,
                      no differences between the PPD, AD and control group were
                      apparent based on structural and functional neuroimaging
                      data immediately after childbirth. At 12 weeks postpartum, a
                      significant association was observed between Integrated
                      Local Correlation (LCor) and the Edinburgh Postnatal
                      Depression Score (EPDS). Our findings do not support the
                      notion that the brain's structural and resting-state
                      functional alterations, if present, can be used as an early
                      biomarker of PPD or AD. However, effects may become apparent
                      if continuous measures of symptom severity are chosen.},
      cin          = {INM-7 / INM-10},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34193913},
      UT           = {WOS:000671789900004},
      doi          = {10.1038/s41598-021-92882-w},
      url          = {https://juser.fz-juelich.de/record/893852},
}