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| Hauptseite > Publikationsdatenbank > Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non‐transfusion‐dependent β‐thalassaemia > print |
| Hauptseite > Publikationsdatenbank > Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non‐transfusion‐dependent β‐thalassaemia > print |
| 001 | 893884 | ||
| 005 | 20211018113109.0 | ||
| 024 | 7 | _ | |a 10.1111/bjh.17479 |2 doi |
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| 024 | 7 | _ | |a 1365-2141 |2 ISSN |
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| 100 | 1 | _ | |a Taher, Ali T. |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non‐transfusion‐dependent β‐thalassaemia |
| 260 | _ | _ | |a Oxford [u.a.] |c 2021 |b Wiley-Blackwell |
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| 520 | _ | _ | |a Bitopertin is a small molecule selective inhibitor of glycine transporter 1 (GlyT1), initially developed to increase brain extracellular levels of glycine in the vicinity of neuronal N-methyl-D-aspartate receptors for the treatment of schizophrenia. GlyT1, the pharmacological target of bitopertin, is also present as a transmembrane transporter in erythroid cells1 and accounts for 50–55% of glycine uptake in human red blood cells (RBCs).2, 3 Erythroid GlyT1 inhibition by bitopertin leads to reduced intracellular glycine availability, interfering with the first step of haem synthesis, in which 5-aminolevulinate synthase catalyses the condensation reaction between glycine and succinyl-coenzyme A, forming 5-aminolevulinic acid.1 |
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| 700 | 1 | _ | |a Viprakasit, Vip |b 1 |
| 700 | 1 | _ | |a Cappellini, Maria Domenica |0 0000-0001-8676-6864 |b 2 |
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| 700 | 1 | _ | |a Cech, Patrick |0 P:(DE-HGF)0 |b 4 |
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| 700 | 1 | _ | |a Brugnara, Carlo |0 0000-0001-8192-8713 |b 12 |
| 773 | _ | _ | |a 10.1111/bjh.17479 |g p. bjh.17479 |0 PERI:(DE-600)1475751-5 |n 2 |p 474–481 |t British journal of haematology |v 194 |y 2021 |x 1365-2141 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/893884/files/bjh.17479-2.pdf |
| 856 | 4 | _ | |y Published on 2021-04-30. Available in OpenAccess from 2022-04-30. |u https://juser.fz-juelich.de/record/893884/files/DV-BIT74876_Bito_Thal_Letter%20to%20editor_12March2021_JD.pdf |
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