TY  - JOUR
AU  - Meer, Selina Beatrice
AU  - Seiler, Theresa
AU  - Buchmann, Christin
AU  - Partalidou, Georgia
AU  - Boden, Sophia
AU  - Loza, Kateryna
AU  - Heggen, Marc
AU  - Linders, Jürgen
AU  - Prymak, Oleg
AU  - Oliveira, Cristiano L. P.
AU  - Hartmann, Laura
AU  - Epple, Matthias
TI  - Controlling the Surface Functionalization of Ultrasmall Gold Nanoparticles by Sequence‐Defined Macromolecules
JO  - Chemistry - a European journal
VL  - 27
IS  - 4
SN  - 1521-3765
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2021-02918
SP  - 1451 - 1464
PY  - 2021
AB  - Ultrasmall gold nanoparticles (diameter about 2 nm) were surface-functionalized with cysteine-carrying precision macromolecules. These consisted of sequence-defined oligo(amidoamine)s (OAAs) with either two or six cysteine molecules for binding to the gold surface and either with or without a PEG chain (3400 Da). They were characterized by 1H NMR spectroscopy, 1H NMR diffusion-ordered spectroscopy (DOSY), small-angle X-ray scattering (SAXS), and high-resolution transmission electron microscopy. The number of precision macromolecules per nanoparticle was determined after fluorescent labeling by UV spectroscopy and also by quantitative 1H NMR spectroscopy. Each nanoparticle carried between 40 and 100 OAA ligands, depending on the number of cysteine units per OAA. The footprint of each ligand was about 0.074 nm2 per cysteine molecule. OAAs are well suited to stabilize ultrasmall gold nanoparticles by selective surface conjugation and can be used to selectively cover their surface. The presence of the PEG chain considerably increased the hydrodynamic diameter of both dissolved macromolecules and macromolecule-conjugated gold nanoparticles.
LB  - PUB:(DE-HGF)16
C6  - 32959929
UR  - <Go to ISI:>//WOS:000598647300001
DO  - DOI:10.1002/chem.202003804
UR  - https://juser.fz-juelich.de/record/893906
ER  -