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000894129 1001_ $$00000-0003-2380-6069$$aLuchini, Alessandra$$b0$$eCorresponding author
000894129 245__ $$aStructural Organization of Cardiolipin-Containing Vesicles as Models of the Bacterial Cytoplasmic Membrane
000894129 260__ $$aWashington, DC$$bACS Publ.$$c2021
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000894129 520__ $$aThe bacterial cytoplasmic membrane is the innermost bacterial membrane and is mainly composed of three different phospholipid species, i.e., phosphoethanolamine (PE), phosphoglycerol (PG), and cardiolipin (CL). In particular, PG and CL are responsible for the negative charge of the membrane and are often the targets of cationic antimicrobial agents. The growing resistance of bacteria toward the available antibiotics requires the development of new and more efficient antibacterial drugs. In this context, studying the physicochemical properties of the bacterial cytoplasmic membrane is pivotal for understanding drug–membrane interactions at the molecular level as well as for designing drug-testing platforms. Here, we discuss the preparation and characterization of PE/PG/CL vesicle suspensions, which contain all of the main lipid components of the bacterial cytoplasmic membrane. The vesicle suspensions were characterized by means of small-angle neutron scattering, dynamic light scattering, and electron paramagnetic spectroscopy. By combining solution scattering and spectroscopy techniques, we propose a detailed description of the impact of different CL concentrations on the structure and dynamics of the PE/PG bilayer. CL induces the formation of thicker bilayers, which exhibit higher curvature and are overall more fluid. The experimental results contribute to shed light on the structure and dynamics of relevant model systems of the bacterial cytoplasmic membrane.
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000894129 7001_ $$0P:(DE-HGF)0$$aCavasso, Domenico$$b1
000894129 7001_ $$0P:(DE-Juel1)130905$$aRadulescu, Aurel$$b2
000894129 7001_ $$00000-0001-6383-8618$$aD’Errico, Gerardino$$b3
000894129 7001_ $$00000-0002-1105-4237$$aPaduano, Luigi$$b4
000894129 7001_ $$00000-0003-3389-6942$$aVitiello, Giuseppe$$b5$$eCorresponding author
000894129 773__ $$0PERI:(DE-600)2005937-1$$a10.1021/acs.langmuir.1c00981$$gVol. 37, no. 28, p. 8508 - 8516$$n28$$p8508 - 8516$$tLangmuir$$v37$$x1520-5827$$y2021
000894129 8564_ $$uhttps://juser.fz-juelich.de/record/894129/files/Manuscript_Langmuir_FINAL.pdf$$yPublished on 2021-07-02. Available in OpenAccess from 2022-07-02.
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