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@ARTICLE{Luchini:894129,
author = {Luchini, Alessandra and Cavasso, Domenico and Radulescu,
Aurel and D’Errico, Gerardino and Paduano, Luigi and
Vitiello, Giuseppe},
title = {{S}tructural {O}rganization of {C}ardiolipin-{C}ontaining
{V}esicles as {M}odels of the {B}acterial {C}ytoplasmic
{M}embrane},
journal = {Langmuir},
volume = {37},
number = {28},
issn = {1520-5827},
address = {Washington, DC},
publisher = {ACS Publ.},
reportid = {FZJ-2021-03056},
pages = {8508 - 8516},
year = {2021},
abstract = {The bacterial cytoplasmic membrane is the innermost
bacterial membrane and is mainly composed of three different
phospholipid species, i.e., phosphoethanolamine (PE),
phosphoglycerol (PG), and cardiolipin (CL). In particular,
PG and CL are responsible for the negative charge of the
membrane and are often the targets of cationic antimicrobial
agents. The growing resistance of bacteria toward the
available antibiotics requires the development of new and
more efficient antibacterial drugs. In this context,
studying the physicochemical properties of the bacterial
cytoplasmic membrane is pivotal for understanding
drug–membrane interactions at the molecular level as well
as for designing drug-testing platforms. Here, we discuss
the preparation and characterization of PE/PG/CL vesicle
suspensions, which contain all of the main lipid components
of the bacterial cytoplasmic membrane. The vesicle
suspensions were characterized by means of small-angle
neutron scattering, dynamic light scattering, and electron
paramagnetic spectroscopy. By combining solution scattering
and spectroscopy techniques, we propose a detailed
description of the impact of different CL concentrations on
the structure and dynamics of the PE/PG bilayer. CL induces
the formation of thicker bilayers, which exhibit higher
curvature and are overall more fluid. The experimental
results contribute to shed light on the structure and
dynamics of relevant model systems of the bacterial
cytoplasmic membrane.},
cin = {JCNS-FRM-II / MLZ / JCNS-4 / JCNS-1},
ddc = {540},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 / I:(DE-588b)4597118-3 /
I:(DE-Juel1)JCNS-4-20201012 / I:(DE-Juel1)JCNS-1-20110106},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
(POF4-6G4) / 632 - Materials – Quantum, Complex and
Functional Materials (POF4-632)},
pid = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
experiment = {EXP:(DE-MLZ)KWS2-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {34213914},
UT = {WOS:000695298500015},
doi = {10.1021/acs.langmuir.1c00981},
url = {https://juser.fz-juelich.de/record/894129},
}