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000894170 1001_ $$00000-0003-4403-0757$$aHöhfeld, Jörg$$b0$$eCorresponding author
000894170 245__ $$aMaintaining proteostasis under mechanical stress
000894170 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2021
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000894170 520__ $$aCell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.
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000894170 7001_ $$0P:(DE-HGF)0$$aBenzing, Thomas$$b1
000894170 7001_ $$00000-0003-1786-8853$$aBloch, Wilhelm$$b2
000894170 7001_ $$0P:(DE-HGF)0$$aFürst, Dieter O$$b3
000894170 7001_ $$0P:(DE-HGF)0$$aGehlert, Sebastian$$b4
000894170 7001_ $$0P:(DE-HGF)0$$aHesse, Michael$$b5
000894170 7001_ $$0P:(DE-Juel1)128817$$aHoffmann, Bernd$$b6$$ufzj
000894170 7001_ $$00000-0002-4734-9352$$aHoppe, Thorsten$$b7
000894170 7001_ $$0P:(DE-Juel1)162356$$aHuesgen, Pitter F$$b8
000894170 7001_ $$00000-0001-8142-3504$$aKöhn, Maja$$b9
000894170 7001_ $$0P:(DE-HGF)0$$aKolanus, Waldemar$$b10
000894170 7001_ $$0P:(DE-Juel1)128833$$aMerkel, Rudolf$$b11
000894170 7001_ $$0P:(DE-HGF)0$$aNiessen, Carien M$$b12
000894170 7001_ $$00000-0002-5110-4462$$aPokrzywa, Wojciech$$b13
000894170 7001_ $$00000-0002-9252-1342$$aRinschen, Markus M$$b14
000894170 7001_ $$00000-0003-4800-6332$$aWachten, Dagmar$$b15
000894170 7001_ $$00000-0001-5096-1975$$aWarscheid, Bettina$$b16
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