TY  - JOUR
AU  - Höhfeld, Jörg
AU  - Benzing, Thomas
AU  - Bloch, Wilhelm
AU  - Fürst, Dieter O
AU  - Gehlert, Sebastian
AU  - Hesse, Michael
AU  - Hoffmann, Bernd
AU  - Hoppe, Thorsten
AU  - Huesgen, Pitter F
AU  - Köhn, Maja
AU  - Kolanus, Waldemar
AU  - Merkel, Rudolf
AU  - Niessen, Carien M
AU  - Pokrzywa, Wojciech
AU  - Rinschen, Markus M
AU  - Wachten, Dagmar
AU  - Warscheid, Bettina
TI  - Maintaining proteostasis under mechanical stress
JO  - EMBO reports
VL  - 22
SN  - 1469-3178
CY  - Hoboken, NJ [u.a.]
PB  - Wiley
M1  - FZJ-2021-03072
SP  - e52507
PY  - 2021
AB  - Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.
LB  - PUB:(DE-HGF)16
C6  - 34309183
UR  - <Go to ISI:>//WOS:000678791100001
DO  - DOI:10.15252/embr.202152507
UR  - https://juser.fz-juelich.de/record/894170
ER  -