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@ARTICLE{Hhfeld:894170,
      author       = {Höhfeld, Jörg and Benzing, Thomas and Bloch, Wilhelm and
                      Fürst, Dieter O and Gehlert, Sebastian and Hesse, Michael
                      and Hoffmann, Bernd and Hoppe, Thorsten and Huesgen, Pitter
                      F and Köhn, Maja and Kolanus, Waldemar and Merkel, Rudolf
                      and Niessen, Carien M and Pokrzywa, Wojciech and Rinschen,
                      Markus M and Wachten, Dagmar and Warscheid, Bettina},
      title        = {{M}aintaining proteostasis under mechanical stress},
      journal      = {EMBO reports},
      volume       = {22},
      issn         = {1469-3178},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2021-03072},
      pages        = {e52507},
      year         = {2021},
      abstract     = {Cell survival, tissue integrity and organismal health
                      depend on the ability to maintain functional protein
                      networks even under conditions that threaten protein
                      integrity. Protection against such stress conditions
                      involves the adaptation of folding and degradation
                      machineries, which help to preserve the protein network by
                      facilitating the refolding or disposal of damaged proteins.
                      In multicellular organisms, cells are permanently exposed to
                      stress resulting from mechanical forces. Yet, for long time
                      mechanical stress was not recognized as a primary stressor
                      that perturbs protein structure and threatens proteome
                      integrity. The identification and characterization of
                      protein folding and degradation systems, which handle
                      force-unfolded proteins, marks a turning point in this
                      regard. It has become apparent that mechanical stress
                      protection operates during cell differentiation, adhesion
                      and migration and is essential for maintaining tissues such
                      as skeletal muscle, heart and kidney as well as the immune
                      system. Here, we provide an overview of recent advances in
                      our understanding of mechanical stress protection.},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project 273723265 - Mechanosensation und
                      Mechanoreaktion in epidermalen Systemen},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)273723265},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34309183},
      UT           = {WOS:000678791100001},
      doi          = {10.15252/embr.202152507},
      url          = {https://juser.fz-juelich.de/record/894170},
}