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000894173 1001_ $$0P:(DE-Juel1)176295$$aPüllen, Robin$$b0$$ufzj
000894173 245__ $$aSkin under Strain: From Epithelial Model Tissues to Adult Epithelia
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000894173 520__ $$aFormation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dramatically. However, comparative studies between embryonic and adult skin in comparison to skin equivalents are still scarce which is especially due to the lack of appropriate measurement systems with sufficient accuracy and long-term tissue compatibility. Our studies fill this gap by developing a combined bioreactor and tensile testing machine for biomechanical analysis of living epithelia. Based on this tissue stretcher, our data clearly show that viscoelastic and plastic deformation behavior of embryonic and adult skin differ significantly. Tissue responses to static strain compared to cyclic strain also show a clear dependence on differentiation stage. Multilayered unkeratinized epidermis equivalents, on the other hand, respond very similar to mechanical stretch as adult tissue. This mechanical similarity is even more evident after a single cycle of mechanical preconditioning. Our studies therefore suggest that skin equivalents are well suited model systems to analyze cellular interactions of epidermal cells in natural tissues
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000894173 536__ $$0G:(GEPRIS)273723265$$aDFG project 273723265 - Mechanosensation und Mechanoreaktion in epidermalen Systemen $$c273723265$$x1
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000894173 7001_ $$0P:(DE-Juel1)169948$$aKonrad, Jens$$b1$$ufzj
000894173 7001_ $$0P:(DE-Juel1)128833$$aMerkel, Rudolf$$b2
000894173 7001_ $$0P:(DE-Juel1)128817$$aHoffmann, Bernd$$b3$$eCorresponding author
000894173 773__ $$0PERI:(DE-600)2661518-6$$a10.3390/cells10071834$$gVol. 10, no. 7, p. 1834 -$$n7$$p1834 -$$tCells$$v10$$x2073-4409$$y2021
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