% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Pllen:894173,
      author       = {Püllen, Robin and Konrad, Jens and Merkel, Rudolf and
                      Hoffmann, Bernd},
      title        = {{S}kin under {S}train: {F}rom {E}pithelial {M}odel
                      {T}issues to {A}dult {E}pithelia},
      journal      = {Cells},
      volume       = {10},
      number       = {7},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-03075},
      pages        = {1834 -},
      year         = {2021},
      abstract     = {Formation of a barrier capable of protecting tissue from
                      external damage, chemical factors, and pathogens is one of
                      the main functions of the epidermis. Furthermore, upon
                      development and during aging, mechanoprotective epidermal
                      functions change dramatically. However, comparative studies
                      between embryonic and adult skin in comparison to skin
                      equivalents are still scarce which is especially due to the
                      lack of appropriate measurement systems with sufficient
                      accuracy and long-term tissue compatibility. Our studies
                      fill this gap by developing a combined bioreactor and
                      tensile testing machine for biomechanical analysis of living
                      epithelia. Based on this tissue stretcher, our data clearly
                      show that viscoelastic and plastic deformation behavior of
                      embryonic and adult skin differ significantly. Tissue
                      responses to static strain compared to cyclic strain also
                      show a clear dependence on differentiation stage.
                      Multilayered unkeratinized epidermis equivalents, on the
                      other hand, respond very similar to mechanical stretch as
                      adult tissue. This mechanical similarity is even more
                      evident after a single cycle of mechanical preconditioning.
                      Our studies therefore suggest that skin equivalents are well
                      suited model systems to analyze cellular interactions of
                      epidermal cells in natural tissues},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524) / DFG project 273723265 - Mechanosensation und
                      Mechanoreaktion in epidermalen Systemen},
      pid          = {G:(DE-HGF)POF4-5243 / G:(GEPRIS)273723265},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34360001},
      UT           = {WOS:000676829000001},
      doi          = {10.3390/cells10071834},
      url          = {https://juser.fz-juelich.de/record/894173},
}