TY  - JOUR
AU  - Wolf, Sabrina
AU  - Becker, Judith
AU  - Tsuge, Yota
AU  - Kawaguchi, Hideo
AU  - Kondo, Akihiko
AU  - Marienhagen, Jan
AU  - Bott, Michael
AU  - Wendisch, Volker F.
AU  - Wittmann, Christoph
TI  - Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being
JO  - Essays in biochemistry
VL  - 65
IS  - 2
SN  - 1744-1358
CY  - London
PB  - Portland Press
M1  - FZJ-2021-03237
SP  - 197 - 212
PY  - 2021
N1  - Biotechnologie 1
AB  - The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial biotechnology and has become famous for its power to synthetise amino acids and a range of bulk chemicals at high titre and yield. The product portfolio of the microbe is continuously expanding. Moreover, metabolically engineered strains of C. glutamicum produce more than 30 high value active ingredients, including signature molecules of raspberry, savoury, and orange flavours, sun blockers, anti-ageing sugars, and polymers for regenerative medicine. Herein, we highlight recent advances in engineering of the microbe into novel cell factories that overproduce these precious molecules from pioneering proofs-of-concept up to industrial productivity.
LB  - PUB:(DE-HGF)16
C6  - 34096577
UR  - <Go to ISI:>//WOS:000684146000006
DO  - DOI:10.1042/EBC20200134
UR  - https://juser.fz-juelich.de/record/894461
ER  -