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@ARTICLE{Wolf:894461,
      author       = {Wolf, Sabrina and Becker, Judith and Tsuge, Yota and
                      Kawaguchi, Hideo and Kondo, Akihiko and Marienhagen, Jan and
                      Bott, Michael and Wendisch, Volker F. and Wittmann,
                      Christoph},
      title        = {{A}dvances in metabolic engineering of {C}orynebacterium
                      glutamicum to produce high-value active ingredients for
                      food, feed, human health, and well-being},
      journal      = {Essays in biochemistry},
      volume       = {65},
      number       = {2},
      issn         = {1744-1358},
      address      = {London},
      publisher    = {Portland Press},
      reportid     = {FZJ-2021-03237},
      pages        = {197 - 212},
      year         = {2021},
      note         = {Biotechnologie 1},
      abstract     = {The soil microbe Corynebacterium glutamicum is a leading
                      workhorse in industrial biotechnology and has become famous
                      for its power to synthetise amino acids and a range of bulk
                      chemicals at high titre and yield. The product portfolio of
                      the microbe is continuously expanding. Moreover,
                      metabolically engineered strains of C. glutamicum produce
                      more than 30 high value active ingredients, including
                      signature molecules of raspberry, savoury, and orange
                      flavours, sun blockers, anti-ageing sugars, and polymers for
                      regenerative medicine. Herein, we highlight recent advances
                      in engineering of the microbe into novel cell factories that
                      overproduce these precious molecules from pioneering
                      proofs-of-concept up to industrial productivity.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34096577},
      UT           = {WOS:000684146000006},
      doi          = {10.1042/EBC20200134},
      url          = {https://juser.fz-juelich.de/record/894461},
}