000894464 001__ 894464
000894464 005__ 20210831151940.0
000894464 0247_ $$2doi$$a10.1042/EBC20200173
000894464 0247_ $$2ISSN$$a0071-1365
000894464 0247_ $$2ISSN$$a1744-1358
000894464 0247_ $$2Handle$$a2128/28476
000894464 0247_ $$2altmetric$$aaltmetric:108773161
000894464 0247_ $$2pmid$$a34223620
000894464 0247_ $$2WOS$$aWOS:000684146000014
000894464 037__ $$aFZJ-2021-03240
000894464 082__ $$a540
000894464 1001_ $$0P:(DE-Juel1)174200$$aBitzenhofer, Nora Lisa$$b0$$eCorresponding author
000894464 245__ $$aTowards robust Pseudomonas cell factories to harbour novel biosynthetic pathways
000894464 260__ $$aLondon$$bPortland Press$$c2021
000894464 3367_ $$2DRIVER$$aarticle
000894464 3367_ $$2DataCite$$aOutput Types/Journal article
000894464 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1628765915_12575
000894464 3367_ $$2BibTeX$$aARTICLE
000894464 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000894464 3367_ $$00$$2EndNote$$aJournal Article
000894464 500__ $$aBiotechnologie 1
000894464 520__ $$aBiotechnological production in bacteria enables access to numerous valuable chemical compounds. Nowadays, advanced molecular genetic toolsets, enzyme engineering as well as the combinatorial use of biocatalysts, pathways, and circuits even bring new-to-nature compounds within reach. However, the associated substrates and biosynthetic products often cause severe chemical stress to the bacterial hosts. Species of the Pseudomonas clade thus represent especially valuable chassis as they are endowed with multiple stress response mechanisms, which allow them to cope with a variety of harmful chemicals. A built-in cell envelope stress response enables fast adaptations that sustain membrane integrity under adverse conditions. Further, effective export machineries can prevent intracellular accumulation of diverse harmful compounds. Finally, toxic chemicals such as reactive aldehydes can be eliminated by oxidation and stress-induced damage can be recovered. Exploiting and engineering these features will be essential to support an effective production of natural compounds and new chemicals. In this article, we therefore discuss major resistance strategies of Pseudomonads along with approaches pursued for their targeted exploitation and engineering in a biotechnological context. We further highlight strategies for the identification of yet unknown tolerance-associated genes and their utilisation for engineering next-generation chassis and finally discuss effective measures for pathway fine-tuning to establish stable cell factories for the effective production of natural compounds and novel biochemicals.
000894464 536__ $$0G:(DE-HGF)POF4-2172$$a2172 - Utilization of renewable carbon and energy sources and engineering of ecosystem functions (POF4-217)$$cPOF4-217$$fPOF IV$$x0
000894464 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000894464 7001_ $$0P:(DE-Juel1)178997$$aKruse, Luzie$$b1
000894464 7001_ $$0P:(DE-Juel1)128936$$aThies, Stephan$$b2
000894464 7001_ $$0P:(DE-Juel1)176854$$aWynands, Benedikt$$b3
000894464 7001_ $$0P:(DE-Juel1)180884$$aLechtenberg, Thorsten$$b4
000894464 7001_ $$0P:(DE-Juel1)186721$$aRönitz, Jakob$$b5
000894464 7001_ $$0P:(DE-HGF)0$$aKozaeva, Ekaterina$$b6
000894464 7001_ $$0P:(DE-HGF)0$$aWirth, Nicolas Thilo$$b7
000894464 7001_ $$0P:(DE-HGF)0$$aEberlein, Christian$$b8
000894464 7001_ $$0P:(DE-Juel1)131457$$aJaeger, Karl-Erich$$b9
000894464 7001_ $$0P:(DE-HGF)0$$aNikel, Pablo Iván$$b10
000894464 7001_ $$0P:(DE-HGF)0$$aHeipieper, Hermann J.$$b11
000894464 7001_ $$0P:(DE-Juel1)176653$$aWierckx, Nick$$b12
000894464 7001_ $$0P:(DE-Juel1)131500$$aLoeschcke, Anita$$b13
000894464 773__ $$0PERI:(DE-600)2242123-3$$a10.1042/EBC20200173$$gVol. 65, no. 2, p. 319 - 336$$n2$$p319 - 336$$tEssays in biochemistry$$v65$$x1744-1358$$y2021
000894464 8564_ $$uhttps://juser.fz-juelich.de/record/894464/files/ebc-2020-0173c.pdf$$yOpenAccess
000894464 909CO $$ooai:juser.fz-juelich.de:894464$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174200$$aForschungszentrum Jülich$$b0$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)178997$$aForschungszentrum Jülich$$b1$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128936$$aForschungszentrum Jülich$$b2$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)176854$$aForschungszentrum Jülich$$b3$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)180884$$aForschungszentrum Jülich$$b4$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)186721$$aForschungszentrum Jülich$$b5$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131457$$aForschungszentrum Jülich$$b9$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)176653$$aForschungszentrum Jülich$$b12$$kFZJ
000894464 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131500$$aForschungszentrum Jülich$$b13$$kFZJ
000894464 9131_ $$0G:(DE-HGF)POF4-217$$1G:(DE-HGF)POF4-210$$2G:(DE-HGF)POF4-200$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-2172$$aDE-HGF$$bForschungsbereich Erde und Umwelt$$lErde im Wandel – Unsere Zukunft nachhaltig gestalten$$vFür eine nachhaltige Bio-Ökonomie – von Ressourcen zu Produkten$$x0
000894464 9141_ $$y2021
000894464 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-02-04
000894464 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000894464 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000894464 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bESSAYS BIOCHEM : 2019$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0400$$2StatID$$aAllianz-Lizenz / DFG$$d2021-02-04$$wger
000894464 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bESSAYS BIOCHEM : 2019$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)1120$$2StatID$$aDBCoverage$$bBIOSIS Reviews Reports And Meetings$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-04
000894464 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-02-04
000894464 920__ $$lyes
000894464 9201_ $$0I:(DE-Juel1)IBG-1-20101118$$kIBG-1$$lBiotechnologie$$x0
000894464 9201_ $$0I:(DE-Juel1)IMET-20090612$$kIMET$$lInstitut für Molekulare Enzymtechnologie (HHUD)$$x1
000894464 980__ $$ajournal
000894464 980__ $$aVDB
000894464 980__ $$aUNRESTRICTED
000894464 980__ $$aI:(DE-Juel1)IBG-1-20101118
000894464 980__ $$aI:(DE-Juel1)IMET-20090612
000894464 9801_ $$aFullTexts