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@ARTICLE{Saberi:894590,
      author       = {Saberi, Amin and Mohammadi, Esmaeil and Zarei, Mojtaba and
                      Eickhoff, Simon B. and Tahmasian, Masoud},
      title        = {{S}tructural and functional neuroimaging of late-life
                      depression: a coordinate-based meta-analysis},
      journal      = {Brain imaging and behavior},
      volume       = {16},
      issn         = {1931-7565},
      address      = {New York, NY [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2021-03297},
      pages        = {518–531},
      year         = {2022},
      abstract     = {Several neuroimaging studies have investigated localized
                      aberrations in brain structure, function or connectivity in
                      late-life depression, but the ensuing results are equivocal
                      and often conflicting. Here, we provide a quantitative
                      consolidation of neuroimaging in late-life depression using
                      coordinate-based meta-analysis by searching multiple
                      databases up to March 2020. Our search revealed 3252 unique
                      records, among which we identified 32 eligible whole-brain
                      neuroimaging publications comparing 674 patients with 568
                      controls. The peak coordinates of group comparisons between
                      the patients and the controls were extracted and then
                      analyzed using activation likelihood estimation method. Our
                      sufficiently powered analysis on all the experiments, and
                      more homogenous subsections of the data
                      (patients > controls, controls > patients, and
                      functional imaging experiments) revealed no significant
                      convergent regional abnormality in late-life depression.
                      This inconsistency might be due to clinical and biological
                      heterogeneity of LLD, as well as experimental (e.g., choice
                      of tasks, image modalities) and analytic flexibility (e.g.,
                      preprocessing and analytic parameters), and distributed
                      patterns of neural abnormalities. Our findings highlight the
                      importance of clinical/biological heterogeneity of late-life
                      depression, in addition to the need for more reproducible
                      research by using pre-registered and standardized protocols
                      on more homogenous populations to identify potential
                      consistent brain abnormalities in late-life depression.},
      cin          = {INM-7},
      ddc          = {150},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34331655},
      UT           = {WOS:000679777400001},
      doi          = {10.1007/s11682-021-00494-9},
      url          = {https://juser.fz-juelich.de/record/894590},
}