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@ARTICLE{Maiti:894665,
      author       = {Maiti, Santanu and Frielinghaus, Henrich and Gräßel,
                      David and Dulle, Martin and Axer, Markus and Förster,
                      Stephan},
      title        = {{D}istribution and orientation of nerve fibers and myelin
                      assembly in a brain section retrieved by small-angle neutron
                      scattering},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-03346},
      pages        = {17306},
      year         = {2021},
      abstract     = {The structural connectivity of the brain has been addressed
                      by various imaging techniques such as diffusion weighted
                      magnetic resonance imaging (DWMRI) or specific microscopic
                      approaches based on histological staining or label-free
                      using polarized light (e.g., three-dimensional Polarized
                      Light Imaging (3D-PLI), Optical Coherence Tomography (OCT)).
                      These methods are sensitive to different properties of the
                      fiber enwrapping myelin sheaths i.e. the distribution of
                      myelin basic protein (histology), the apparent diffusion
                      coefficient of water molecules restricted in their movements
                      by the myelin sheath (DWMRI), and the birefringence of the
                      oriented myelin lipid bilayers (3D-PLI, OCT). We show that
                      the orientation and distribution of nerve fibers as well as
                      myelin in thin brain sections can be determined using
                      scanning small angle neutron scattering (sSANS). Neutrons
                      are scattered from the fiber assembly causing anisotropic
                      diffuse small-angle scattering and Bragg peaks related to
                      the highly ordered periodic myelin multilayer structure. The
                      scattering anisotropy, intensity, and angular position of
                      the Bragg peaks can be mapped across the entire brain
                      section. This enables mapping of the fiber and myelin
                      distribution and their orientation in a thin brain section,
                      which was validated by 3D-PLI. The experiments became
                      possible by optimizing the neutron beam collimation to
                      highest flux and enhancing the myelin contrast by
                      deuteration. This method is very sensitive to small
                      microstructures of biological tissue and can directly
                      extract information on the average fiber orientation and
                      even myelin membrane thickness. The present results pave the
                      way toward bio-imaging for detecting structural aberrations
                      causing neurological diseases in future.},
      cin          = {JCNS-FRM-II / JCNS-4 / MLZ / JCNS-1 / INM-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-4-20201012 / I:(DE-588b)4597118-3 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34453063},
      UT           = {WOS:000691009100022},
      doi          = {10.1038/s41598-021-92995-2},
      url          = {https://juser.fz-juelich.de/record/894665},
}