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@ARTICLE{Stengelin:894716,
      author       = {Stengelin, Elena and Nzigou Mombo, Brice and Mondeshki,
                      Mihail and Beltramo, Guillermo L. and Lange, Martin A. and
                      Schmidt, Patrick and Frerichs, Hajo and Wegner, Serafine V.
                      and Seiffert, Sebastian},
      title        = {{R}ational {D}esign of {T}hermoresponsive {M}icrogel
                      {T}emplates with {P}olydopamine {S}urface {C}oating for
                      {M}icrotissue {A}pplications},
      journal      = {Macromolecular bioscience},
      volume       = {21},
      number       = {9},
      issn         = {1616-5195},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2021-03368},
      pages        = {2100209},
      year         = {2021},
      abstract     = {Functional microgels provide a versatile basis for
                      synthetic in vitro platforms as alternatives to animal
                      experiments. The tuning of the physical, chemical, and
                      biological properties of synthetic microgels can be achieved
                      by blending suitable polymers and formulating them such to
                      reflect the heterogenous and complex nature of biological
                      tissues. Based on this premise, this paper introduces the
                      development of volume-switchable core–shell microgels as
                      3D templates to enable cell growth for microtissue
                      applications, using a systematic approach to tune the
                      microgel properties based on a deep conceptual and practical
                      understanding. Microscopic microgel design, such as the
                      tailoring of the microgel size and spherical shape, is
                      achieved by droplet-based microfluidics, while on a
                      nanoscopic scale, a thermoresponsive polymer basis,
                      poly(N-isopropylacrylamide) (PNIPAAm), is used to provide
                      the microgel volume switchability. Since PNIPAAm has only
                      limited cell-growth promoting properties, the cell adhesion
                      on the microgel is further improved by surface modification
                      with polydopamine, which only slightly affects the microgel
                      properties, thereby simplifying the system. To further tune
                      the microgel thermoresponsiveness, different amounts of
                      N-hydroxyethylacrylamide are incorporated into the PNIPAAm
                      network. In a final step, cell growth on the microgel
                      surface is investigated, both at a single microgel platform
                      and in spheroidal cell structures.},
      cin          = {IBI-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34342150},
      UT           = {WOS:000680490200001},
      doi          = {10.1002/mabi.202100209},
      url          = {https://juser.fz-juelich.de/record/894716},
}