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000894890 1001_ $$0P:(DE-HGF)0$$aMoe-Lange, Jacob$$b0$$eCorresponding author
000894890 245__ $$aInterdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling
000894890 260__ $$aWashington, DC [u.a.]$$bAssoc.$$c2021
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000894890 520__ $$aGlutamate has dual roles in metabolism and signaling; thus, signaling functions must be isolatable and distinct from metabolic fluctuations, as seen in low-glutamate domains at synapses. In plants, wounding triggers electrical and calcium (Ca2+) signaling, which involve homologs of mammalian glutamate receptors. The hydraulic dispersal and squeeze-cell hypotheses implicate pressure as a key component of systemic signaling. Here, we identify the stretch-activated anion channel MSL10 as necessary for proper wound-induced electrical and Ca2+ signaling. Wound gene induction, genetics, and Ca2+ imaging indicate that MSL10 acts in the same pathway as the glutamate receptor–like proteins (GLRs). Analogous to mammalian NMDA glutamate receptors, GLRs may serve as coincidence detectors gated by the combined requirement for ligand binding and membrane depolarization, here mediated by stretch activation of MSL10. This study provides a molecular genetic basis for a role of mechanical signal perception and the transmission of long-distance electrical and Ca2+ signals in plants.
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000894890 7001_ $$0P:(DE-HGF)0$$aGappel, Nicoline M.$$b1
000894890 7001_ $$0P:(DE-HGF)0$$aMachado, Mackenzie$$b2
000894890 7001_ $$0P:(DE-HGF)0$$aWudick, Michael M.$$b3
000894890 7001_ $$00000-0001-6169-047X$$aSies, Cosima S. A.$$b4
000894890 7001_ $$0P:(DE-Juel1)187014$$aSchott, Stephan$$b5
000894890 7001_ $$00000-0003-4411-7342$$aBonus, Michele$$b6
000894890 7001_ $$0P:(DE-HGF)0$$aMishra, Swastik$$b7
000894890 7001_ $$00000-0002-2707-2771$$aHartwig, Thomas$$b8
000894890 7001_ $$00000-0002-8009-3635$$aBezrutczyk, Margaret$$b9
000894890 7001_ $$00000-0003-0547-7636$$aBasu, Debarati$$b10
000894890 7001_ $$0P:(DE-HGF)0$$aFarmer, Edward E.$$b11
000894890 7001_ $$0P:(DE-Juel1)172663$$aGohlke, Holger$$b12
000894890 7001_ $$00000-0002-5648-8602$$aMalkovskiy, Andrey$$b13
000894890 7001_ $$00000-0002-4246-065X$$aHaswell, Elizabeth S.$$b14
000894890 7001_ $$00000-0003-3940-1621$$aLercher, Martin J.$$b15
000894890 7001_ $$00000-0001-6522-7722$$aEhrhardt, David W.$$b16
000894890 7001_ $$00000-0001-6465-0115$$aFrommer, Wolf B.$$b17$$eCorresponding author
000894890 7001_ $$00000-0003-2568-7323$$aKleist, Thomas J.$$b18
000894890 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.abg4298$$gVol. 7, no. 37$$n37$$peabg4298$$tScience advances$$v7$$x2375-2548$$y2021
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