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@ARTICLE{MoeLange:894890,
      author       = {Moe-Lange, Jacob and Gappel, Nicoline M. and Machado,
                      Mackenzie and Wudick, Michael M. and Sies, Cosima S. A. and
                      Schott, Stephan and Bonus, Michele and Mishra, Swastik and
                      Hartwig, Thomas and Bezrutczyk, Margaret and Basu, Debarati
                      and Farmer, Edward E. and Gohlke, Holger and Malkovskiy,
                      Andrey and Haswell, Elizabeth S. and Lercher, Martin J. and
                      Ehrhardt, David W. and Frommer, Wolf B. and Kleist, Thomas
                      J.},
      title        = {{I}nterdependence of a mechanosensitive anion channel and
                      glutamate receptors in distal wound signaling},
      journal      = {Science advances},
      volume       = {7},
      number       = {37},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {FZJ-2021-03456},
      pages        = {eabg4298},
      year         = {2021},
      abstract     = {Glutamate has dual roles in metabolism and signaling; thus,
                      signaling functions must be isolatable and distinct from
                      metabolic fluctuations, as seen in low-glutamate domains at
                      synapses. In plants, wounding triggers electrical and
                      calcium (Ca2+) signaling, which involve homologs of
                      mammalian glutamate receptors. The hydraulic dispersal and
                      squeeze-cell hypotheses implicate pressure as a key
                      component of systemic signaling. Here, we identify the
                      stretch-activated anion channel MSL10 as necessary for
                      proper wound-induced electrical and Ca2+ signaling. Wound
                      gene induction, genetics, and Ca2+ imaging indicate that
                      MSL10 acts in the same pathway as the glutamate
                      receptor–like proteins (GLRs). Analogous to mammalian NMDA
                      glutamate receptors, GLRs may serve as coincidence detectors
                      gated by the combined requirement for ligand binding and
                      membrane depolarization, here mediated by stretch activation
                      of MSL10. This study provides a molecular genetic basis for
                      a role of mechanical signal perception and the transmission
                      of long-distance electrical and Ca2+ signals in plants.},
      cin          = {JSC / NIC / IBI-7 / IBG-4},
      ddc          = {500},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)NIC-20090406 /
                      I:(DE-Juel1)IBI-7-20200312 / I:(DE-Juel1)IBG-4-20200403},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / 2171 - Biological
                      and environmental resources for sustainable use (POF4-217) /
                      2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217) /
                      Forschergruppe Gohlke $(hkf7_20200501)$},
      pid          = {G:(DE-HGF)POF4-5111 / G:(DE-HGF)POF4-2171 /
                      G:(DE-HGF)POF4-2172 / $G:(DE-Juel1)hkf7_20200501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34516872},
      UT           = {WOS:000695713400002},
      doi          = {10.1126/sciadv.abg4298},
      url          = {https://juser.fz-juelich.de/record/894890},
}