%0 Journal Article
%A Hill-Bowen, Lauren D.
%A Riedel, Michael C.
%A Poudel, Ranjita
%A Salo, Taylor
%A Flannery, Jessica S.
%A Camilleri, Julia A.
%A Eickhoff, Simon B.
%A Laird, Angela R.
%A Sutherland, Matthew T.
%T The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli
%J Neuroscience & biobehavioral reviews
%V 130
%@ 0149-7634
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2021-03482
%P 201 - 213
%D 2021
%X The cue-reactivity paradigm is a widely adopted neuroimaging probe engendering brain activity linked with attentional, affective, and reward processes following presentation of appetitive stimuli. Given the multiple mental operations invoked, we sought to decompose cue-related brain activity into constituent components employing emergent meta-analytic techniques when considering drug and natural reward-related cues. We conducted coordinate-based meta-analyses delineating common and distinct brain activity convergence across cue-reactivity studies (N = 196 articles) involving drug (n = 133) or natural (n = 63) visual stimuli. Across all studies, convergence was observed in limbic, cingulate, insula, and fronto-parieto-occipital regions. Drug-distinct convergence was observed in posterior cingulate, dorsolateral prefrontal, and temporo-parietal regions, whereas distinct-natural convergence was observed in thalamic, insular, orbitofrontal, and occipital regions. We characterized connectivity profiles of identified regions by leveraging task-independent and task-dependent MRI datasets, grouped these profiles into subnetworks, and linked each with putative mental operations. Outcomes suggest multifaceted brain activity during cue-reactivity can be decomposed into elemental processes and indicate that while drugs of abuse usurp the brain's natural-reward-processing system, some regions appear distinct to drug cue-reactivity.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34400176
%U <Go to ISI:>//WOS:000709411900001
%R 10.1016/j.neubiorev.2021.08.010
%U https://juser.fz-juelich.de/record/894920