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@ARTICLE{Tamgney:894934,
      author       = {Tamgüney, Erdem Gültekin},
      title        = {{R}ecurring {G}astrointestinal {I}nfections {I}ncrease the
                      {R}isk of {D}ementia},
      journal      = {Journal of Alzheimer's disease},
      volume       = {84},
      number       = {2},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2021-03493},
      pages        = {797-806},
      year         = {2021},
      abstract     = {Background:Gastrointestinal infections cause significant
                      health problems, including those affecting the immune,
                      musculoskeletal, and nervous system, and are one of the
                      leading causes for death worldwide. Recent findings suggest
                      that microbiota of the gastrointestinal tract contribute to
                      dementia.Objective:In this nested case-control study we
                      investigated the role of common gastrointestinal infections
                      on the subsequent risk of dementia.Methods:We used a
                      longitudinal sample of 202,806 individuals from health
                      claims data of the largest German health insurer and applied
                      a nested case-control design with 23,354 initial dementia
                      cases between 2006 and 2014 and 23,354 matched controls. We
                      used conditional logistic regression to compute odds ratios
                      (ORs) for dementia and corresponding $95\%confidence$
                      intervals (CIs), adjusting for potential
                      confounders.Results:The risk of dementia was increased in
                      patients with recurring incidences of quarters with
                      diagnosed gastrointestinal infections when compared to the
                      unexposed population (one quarter: OR = 1.49,
                      $95\%CI = 1.40–1.58;$ two quarters: OR = 1.70,
                      $95\%CI = 1.51–1.91;$ three or more quarters:
                      OR = 1.64, $95\%CI = 1.40–1.93),$ adjusted for
                      potential confounders.Conclusion:Our findings suggest that
                      recurring gastrointestinal infections are associated with an
                      increased risk of subsequent dementia.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34602468},
      UT           = {WOS:000718167200026},
      doi          = {10.3233/JAD-210316},
      url          = {https://juser.fz-juelich.de/record/894934},
}