TY  - JOUR
AU  - Kraljević, Nevena
AU  - Schaare, Lina
AU  - Eickhoff, Simon B.
AU  - Kochunov, Peter
AU  - Yeo, B. T. Thomas
AU  - Kharabian Masouleh, Shahrzad
AU  - Valk, Sofie
TI  - Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex
JO  - NeuroImage
VL  - 243
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2021-03495
SP  - 118561 -
PY  - 2021
AB  - Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the pedigree-based Human Connectome Project sample (N = 1091). Both cognitive and affective trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition. Decomposing the phenotypic correlations into genetic and environmental components showed that the associations were accounted for by shared genetic effects between the traits. Quantitative functional decoding of the left superior frontal cortex further indicated that this region is associated with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness.
LB  - PUB:(DE-HGF)16
C6  - pmid:34506912
UR  - <Go to ISI:>//WOS:000697938900008
DO  - DOI:10.1016/j.neuroimage.2021.118561
UR  - https://juser.fz-juelich.de/record/894936
ER  -