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@ARTICLE{Kraljevi:894936,
      author       = {Kraljević, Nevena and Schaare, Lina and Eickhoff, Simon B.
                      and Kochunov, Peter and Yeo, B. T. Thomas and Kharabian
                      Masouleh, Shahrzad and Valk, Sofie},
      title        = {{B}ehavioral, {A}natomical and {H}eritable {C}onvergence of
                      {A}ffect and {C}ognition in {S}uperior {F}rontal {C}ortex},
      journal      = {NeuroImage},
      volume       = {243},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2021-03495},
      pages        = {118561 -},
      year         = {2021},
      abstract     = {Cognitive abilities and affective experience are key human
                      traits that are interrelated in behavior and brain.
                      Individual variation of cognitive and affective traits, as
                      well as brain structure, has been shown to partly underlie
                      genetic effects. However, to what extent affect and
                      cognition have a shared genetic relationship with local
                      brain structure is incompletely understood. Here we studied
                      phenotypic and genetic correlations of cognitive and
                      affective traits in behavior and brain structure (cortical
                      thickness, surface area and subcortical volumes) in the
                      pedigree-based Human Connectome Project sample (N = 1091).
                      Both cognitive and affective trait scores were highly
                      heritable and showed significant phenotypic correlation on
                      the behavioral level. Cortical thickness in the left
                      superior frontal cortex showed a phenotypic association with
                      both affect and cognition. Decomposing the phenotypic
                      correlations into genetic and environmental components
                      showed that the associations were accounted for by shared
                      genetic effects between the traits. Quantitative functional
                      decoding of the left superior frontal cortex further
                      indicated that this region is associated with cognitive and
                      emotional functioning. This study provides a multi-level
                      approach to study the association between affect and
                      cognition and suggests a convergence of both in superior
                      frontal cortical thickness.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34506912},
      UT           = {WOS:000697938900008},
      doi          = {10.1016/j.neuroimage.2021.118561},
      url          = {https://juser.fz-juelich.de/record/894936},
}