%0 Journal Article
%A Orlovskaya, Viktoriya V.
%A Craig, Austin S.
%A Fedorova, Olga S.
%A Kuznetsova, Olga F.
%A Neumaier, Bernd
%A Krasikova, Raisa N.
%A Zlatopolskiy, Boris D.
%T Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling
%J Molecules
%V 26
%N 18
%@ 1420-3049
%C Basel
%I MDPI
%M FZJ-2021-03504
%P 5550
%D 2021
%X 6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-L-[18F]FMT using alcoholenhancedCu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0  3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-L-[18F]FMT in the clinic.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 34577021
%U <Go to ISI:>//WOS:000701791500001
%R 10.3390/molecules26185550
%U https://juser.fz-juelich.de/record/894974