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000894974 1001_ $$0P:(DE-HGF)0$$aOrlovskaya, Viktoriya V.$$b0
000894974 245__ $$aProduction of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling
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000894974 520__ $$a6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-L-[18F]FMT using alcoholenhancedCu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0  3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-L-[18F]FMT in the clinic.
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000894974 7001_ $$0P:(DE-Juel1)176281$$aCraig, Austin S.$$b1
000894974 7001_ $$0P:(DE-HGF)0$$aFedorova, Olga S.$$b2
000894974 7001_ $$0P:(DE-HGF)0$$aKuznetsova, Olga F.$$b3
000894974 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b4$$eCorresponding author
000894974 7001_ $$0P:(DE-HGF)0$$aKrasikova, Raisa N.$$b5
000894974 7001_ $$0P:(DE-Juel1)176188$$aZlatopolskiy, Boris D.$$b6
000894974 773__ $$0PERI:(DE-600)2008644-1$$a10.3390/molecules26185550$$gVol. 26, no. 18, p. 5550 -$$n18$$p5550$$tMolecules$$v26$$x1420-3049$$y2021
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