TY  - JOUR
AU  - Orlovskaya, Viktoriya V.
AU  - Craig, Austin S.
AU  - Fedorova, Olga S.
AU  - Kuznetsova, Olga F.
AU  - Neumaier, Bernd
AU  - Krasikova, Raisa N.
AU  - Zlatopolskiy, Boris D.
TI  - Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling
JO  - Molecules
VL  - 26
IS  - 18
SN  - 1420-3049
CY  - Basel
PB  - MDPI
M1  - FZJ-2021-03504
SP  - 5550
PY  - 2021
AB  - 6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-L-[18F]FMT using alcoholenhancedCu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0  3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-L-[18F]FMT in the clinic.
LB  - PUB:(DE-HGF)16
C6  - 34577021
UR  - <Go to ISI:>//WOS:000701791500001
DO  - DOI:10.3390/molecules26185550
UR  - https://juser.fz-juelich.de/record/894974
ER  -