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@ARTICLE{Orlovskaya:894974,
      author       = {Orlovskaya, Viktoriya V. and Craig, Austin S. and Fedorova,
                      Olga S. and Kuznetsova, Olga F. and Neumaier, Bernd and
                      Krasikova, Raisa N. and Zlatopolskiy, Boris D.},
      title        = {{P}roduction of 6-{L}-[18{F}]{F}luoro-m-tyrosine in an
                      {A}utomated {S}ynthesis {M}odule for 11{C}-{L}abeling},
      journal      = {Molecules},
      volume       = {26},
      number       = {18},
      issn         = {1420-3049},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-03504},
      pages        = {5550},
      year         = {2021},
      abstract     = {6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a
                      valuable alternative to 6-L-[18F]FDOPA which is
                      conventionally used for the diagnosis and staging of
                      Parkinson’s disease. However, clinicalapplications of
                      6-L-[18F]FMT have been limited by the paucity of practical
                      production methods for its automated production. Herein we
                      describe the practical preparation of 6-L-[18F]FMT using
                      alcoholenhancedCu-mediated radiofluorination of
                      Bpin-substituted chiral Ni(II) complex in the presence of
                      non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as
                      reaction solvent. A simple and fast radiolabeling procedure
                      afforded the tracer in 20.0 $3.0\%$ activity yield within 70
                      min. The developed method was directly implemented onto a
                      modified TracerLab FX C Pro platform originally designed for
                      11C-labeling. This method enables an uncomplicated switch
                      between 11C- and 18F-labeling. The simplicity of the
                      developed procedure enables its easy adaptation to other
                      commercially available remote-controlled synthesis units and
                      paves the way for a widespread application of 6-L-[18F]FMT
                      in the clinic.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34577021},
      UT           = {WOS:000701791500001},
      doi          = {10.3390/molecules26185550},
      url          = {https://juser.fz-juelich.de/record/894974},
}