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| Hauptseite > Publikationsdatenbank > Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling > print |
| Hauptseite > Publikationsdatenbank > Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling > print |
| 001 | 894974 | ||
| 005 | 20211018113109.0 | ||
| 024 | 7 | _ | |a 10.3390/molecules26185550 |2 doi |
| 024 | 7 | _ | |a 1420-3049 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2021-03504 |
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| 100 | 1 | _ | |a Orlovskaya, Viktoriya V. |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Production of 6-L-[18F]Fluoro-m-tyrosine in an Automated Synthesis Module for 11C-Labeling |
| 260 | _ | _ | |a Basel |c 2021 |b MDPI |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a 6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-L-[18F]FMT using alcoholenhancedCu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0 3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for 11C-labeling. This method enables an uncomplicated switch between 11C- and 18F-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-L-[18F]FMT in the clinic. |
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| 700 | 1 | _ | |a Craig, Austin S. |0 P:(DE-Juel1)176281 |b 1 |
| 700 | 1 | _ | |a Fedorova, Olga S. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Kuznetsova, Olga F. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Neumaier, Bernd |0 P:(DE-Juel1)166419 |b 4 |e Corresponding author |
| 700 | 1 | _ | |a Krasikova, Raisa N. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Zlatopolskiy, Boris D. |0 P:(DE-Juel1)176188 |b 6 |
| 773 | _ | _ | |a 10.3390/molecules26185550 |g Vol. 26, no. 18, p. 5550 - |0 PERI:(DE-600)2008644-1 |n 18 |p 5550 |t Molecules |v 26 |y 2021 |x 1420-3049 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/894974/files/molecules-26-05550.pdf |y OpenAccess |
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