% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schtz:894976,
      author       = {Schütz, Markus B. and Renner, Alexander M. and Ilyas,
                      Shaista and Lê, Khan and Guliyev, Mehrab and Krapf, Philipp
                      and Neumaier, Bernd and Mathur, Sanjay},
      title        = {18{F}-{L}abeled magnetic nanovectors for bimodal cellular
                      imaging},
      journal      = {Biomaterials science},
      volume       = {9},
      number       = {13},
      issn         = {2047-4849},
      address      = {Cambridge},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2021-03505},
      pages        = {4717 - 4727},
      year         = {2021},
      abstract     = {Surface modification of nanocarriers enables selective
                      attachment to specific molecular targets within a complex
                      biological environment. Besides the enhanced uptake due to
                      specific interactions, the surfaceligands can be utilized
                      for radiolabeling applications for bimodal imaging ensured
                      by positron emission topography (PET) and magnetic resonance
                      imaging (MRI) functions in one source. Herein, we
                      describethe surface functionalization of magnetite (Fe3O4)
                      with folic acid as a target vector. Additionally, the
                      magnetic nanocarriers were conjugated with appropriate
                      ligands for subsequent copper-catalyzed azide–alkyne
                      cycloaddition or carbodiimide coupling reactions to
                      successfully achieve radiolabeling with the PET-emitter 18F.
                      The phase composition (XRD) and size analysis (TEM)
                      confirmed the formation of Fe3O4nanoparticles (6.82 nm ±
                      0.52 nm). The quantification of various surface
                      functionalities was performed by Fourier-transform infrared
                      spectroscopy (FT-IR) and ultraviolet-visible microscopy
                      (UV-Vis). An innovativemagnetic-HPLC method was developed in
                      this work for the determination of the radiochemical yield
                      of the 18F-labeled NPs. The as-prepared Fe3O4 particles
                      demonstrated high radiochemical yields andshowed high
                      cellular uptake in a folate receptor overexpressing MCF-7
                      cell line, validating bimodalimaging chemical design and a
                      magnetic HPLC system. This novel approach, combining folic
                      acidcappedFe3O4 nanocarriers as a targeting vector with 18F
                      labeling, is promising to apply this probe forbimodal
                      PET/MR-studies.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34032225},
      UT           = {WOS:000653661200001},
      doi          = {10.1039/D1BM00616A},
      url          = {https://juser.fz-juelich.de/record/894976},
}