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@ARTICLE{Camargo:896711,
      author       = {Camargo, Luana Cristina and Honold, Dominik and Bauer,
                      Robert and Shah, N. J. and Langen, Karl-Josef and Willbold,
                      Dieter and Kutzsche, Janine and Willuweit, Antje and
                      Schemmert, Sarah},
      title        = {{S}ex-{R}elated {M}otor {D}eficits in the {T}au-{P}301{L}
                      {M}ouse {M}odel},
      journal      = {Biomedicines},
      volume       = {9},
      number       = {9},
      issn         = {2227-9059},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-03544},
      pages        = {1160 -},
      year         = {2021},
      abstract     = {The contribution of mouse models for basic and
                      translational research at different levels is important to
                      understand neurodegenerative diseases, including
                      tauopathies, by studying the alterations in the
                      corresponding mouse models in detail. Moreover, several
                      studies demonstrated that pathological as well as behavioral
                      changes are influenced by the sex. For this purpose, we
                      performed an in-depth characterization of the behavioral
                      alterations in the transgenic Tau-P301L mouse model.
                      Sex-matched wild type and homozygous Tau-P301L mice were
                      tested in a battery of behavioral tests at different ages.
                      Tau-P301L male mice showed olfactory and motor deficits as
                      well as increased Tau pathology, which was not observed in
                      Tau-P301L female mice. Both Tau-P301L male and female mice
                      had phenotypic alterations in the SHIRPA test battery and
                      cognitive deficits in the novel object recognition test.
                      This study demonstrated that Tau-P301L mice have phenotypic
                      alterations, which are in line with the histological changes
                      and with a sex-dependent performance in those tests.
                      Summarized, the Tau-P301L mouse model shows phenotypic
                      alterations due to the presence of neurofibrillary tangles
                      in the brain},
      cin          = {INM-4 / IBI-7 / INM-11 / JARA-BRAIN},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)IBI-7-20200312 /
                      I:(DE-Juel1)INM-11-20170113 / I:(DE-Juel1)VDB1046},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5244 -
                      Information Processing in Neuronal Networks (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34572348},
      UT           = {WOS:000699418900001},
      doi          = {10.3390/biomedicines9091160},
      url          = {https://juser.fz-juelich.de/record/896711},
}