TY  - JOUR
AU  - Mantel, Marvin
AU  - Giesler, Markus
AU  - Guder, Marian
AU  - Rüthlein, Elisabeth
AU  - Hartmann, Laura
AU  - Pietruszka, Jörg
TI  - Lewis Base–Brønsted Acid–Enzyme Catalysis in Enantioselective Multistep One‐Pot Syntheses
JO  - Angewandte Chemie / International edition
VL  - 60
IS  - 30
SN  - 1521-3773
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2021-03552
SP  - 16700 - 16706
PY  - 2021
AB  - Establishing one-pot, multi-step protocols combining different types of catalysts is one important goal for increasing efficiency in modern organic synthesis. In particular, the high potential of biocatalysts still needs to be harvested. Based on an in-depth mechanistic investigation of a new organocatalytic protocol employing two catalysts {1,4-diazabicyclo[2.2.2]octane (DABCO); benzoic acid (BzOH)}, a sequence was established providing starting materials for enzymatic refinement (ene reductase; alcohol dehydrogenase): A gram-scale access to a variety of enantiopure key building blocks for natural product syntheses was enabled utilizing up to six catalytic steps within the same reaction vessel.
LB  - PUB:(DE-HGF)16
C6  - pmid:33856095
UR  - <Go to ISI:>//WOS:000646206600001
DO  - DOI:10.1002/anie.202103406
UR  - https://juser.fz-juelich.de/record/896719
ER  -