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@ARTICLE{Mantel:896719,
author = {Mantel, Marvin and Giesler, Markus and Guder, Marian and
Rüthlein, Elisabeth and Hartmann, Laura and Pietruszka,
Jörg},
title = {{L}ewis {B}ase–{B}rønsted {A}cid–{E}nzyme {C}atalysis
in {E}nantioselective {M}ultistep {O}ne‐{P}ot {S}yntheses},
journal = {Angewandte Chemie / International edition},
volume = {60},
number = {30},
issn = {1521-3773},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2021-03552},
pages = {16700 - 16706},
year = {2021},
abstract = {Establishing one-pot, multi-step protocols combining
different types of catalysts is one important goal for
increasing efficiency in modern organic synthesis. In
particular, the high potential of biocatalysts still needs
to be harvested. Based on an in-depth mechanistic
investigation of a new organocatalytic protocol employing
two catalysts {1,4-diazabicyclo[2.2.2]octane (DABCO);
benzoic acid (BzOH)}, a sequence was established providing
starting materials for enzymatic refinement (ene reductase;
alcohol dehydrogenase): A gram-scale access to a variety of
enantiopure key building blocks for natural product
syntheses was enabled utilizing up to six catalytic steps
within the same reaction vessel.},
cin = {IBOC / IBG-1},
ddc = {540},
cid = {I:(DE-Juel1)IBOC-20090406 / I:(DE-Juel1)IBG-1-20101118},
pnm = {2171 - Biological and environmental resources for
sustainable use (POF4-217)},
pid = {G:(DE-HGF)POF4-2171},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33856095},
UT = {WOS:000646206600001},
doi = {10.1002/anie.202103406},
url = {https://juser.fz-juelich.de/record/896719},
}