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@ARTICLE{Tsitouroudi:896738,
      author       = {Tsitouroudi, Fani and Sarli, Vasiliki and Poulcharidis,
                      Dimitrios and Pitou, Maria and Katranidis, Alexandros and
                      Choli-Papadopoulou, Theodora},
      title        = {{A}za-{R}eversine {P}romotes {R}eprogramming of {L}ung
                      ({MRC}-5) and {D}ifferentiation of {M}esenchymal {C}ells
                      into {O}steoblasts},
      journal      = {Materials},
      volume       = {14},
      number       = {18},
      issn         = {1996-1944},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-03563},
      pages        = {5385 -},
      year         = {2021},
      abstract     = {Reversine or 2-(4-morpholinoanilino)-N6-cyclohexyladenine
                      was originally identified as a small organic molecule that
                      induces dedifferentiation of lineage-committed mouse
                      myoblasts, C2C12, and redirects them into lipocytes or
                      osteoblasts under lineage-specific conditions (LISCs).
                      Further, it was proven that this small molecule can induce
                      cell cycle arrest and apoptosis and thus selectively lead
                      cancer cells to cell death. Further studies demonstrated
                      that reversine, and more specifically the C2 position of the
                      purine ring, can tolerate a wide range of substitutions
                      without activity loss. In this study, a piperazine analog of
                      reversine, also known as aza-reversine, and a biotinylated
                      derivative of aza-reversine were synthesized, and their
                      potential medical applications were investigated by
                      transforming the endoderm originates fetal lung cells
                      (MRC-5) into the mesoderm originated osteoblasts and by
                      differentiating mesenchymal cells into osteoblasts.
                      Moreover, the reprogramming capacity of aza-reversine and
                      biotinylated aza-reversine was investigated against MRC-5
                      cells and mesenchymal cells after the immobilization on
                      PMMA/HEMA polymeric surfaces. The results showed that both
                      aza-reversine and the biofunctionalized, biotinylated analog
                      induced the reprogramming of MRC-5 cells to a more
                      primitive, pluripotent state and can further transform them
                      into osteoblasts under osteogenic culture conditions. These
                      molecules also induced the differentiation of dental and
                      adipose mesenchymal cells to osteoblasts. Thus, the
                      possibility to load a small molecule with useful
                      “information” for delivering that into specific cell
                      targets opens new therapeutic personalized applications.},
      cin          = {IBI-6},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-6-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / 5352 - Understanding the Functionality of Soft
                      Matter and Biomolecular Systems (POF4-535)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(DE-HGF)POF4-5352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34576609},
      UT           = {WOS:000699504300001},
      doi          = {10.3390/ma14185385},
      url          = {https://juser.fz-juelich.de/record/896738},
}