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@ARTICLE{Menzel:897096,
      author       = {Menzel, Miriam and Ritzkowski, Marouan and Reuter, Jan
                      André and Gräßel, David and Amunts, Katrin and Axer,
                      Markus},
      title        = {{S}catterometry {M}easurements with {S}cattered {L}ight
                      {I}maging {E}nable {N}ew {I}nsights into the {B}rain's
                      {N}erve {F}iber {A}rchitecture},
      reportid     = {FZJ-2021-03595},
      year         = {2021},
      note         = {13 pages, 7 figures},
      abstract     = {The correct reconstruction of individual (crossing) nerve
                      fibers is a prerequisite when constructing a detailed
                      network model of the brain. The recently developed technique
                      Scattered Light Imaging (SLI) allows the reconstruction of
                      crossing nerve fiber pathways in whole brain tissue samples
                      with micrometer resolution: The individual fiber
                      orientations are determined by illuminating unstained
                      histological brain sections from different directions,
                      measuring the transmitted scattered light under normal
                      incidence, and studying the light intensity profiles of each
                      pixel in the resulting image series. So far, SLI
                      measurements were performed with a fixed polar angle of
                      illumination and a small number of illumination directions,
                      providing only an estimate of the nerve fiber directions and
                      limited information about the underlying tissue structure.
                      Here, we use an LED display with individually controllable
                      LEDs to measure the full distribution of scattered light
                      behind the sample (scattering pattern) for each image pixel
                      at once, enabling scatterometry measurements of whole brain
                      tissue samples. We compare our results to coherent Fourier
                      scatterometry (raster-scanning the sample with a non-focused
                      laser beam) and previous SLI measurements with fixed polar
                      angle of illumination, using sections from a vervet monkey
                      brain and human optic tracts. Finally, we present SLI
                      scatterometry measurements of a human brain section with 3
                      $\mu$m in-plane resolution, demonstrating that the technique
                      is a powerful approach to gain new insights into the nerve
                      fiber architecture of the human brain.},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5254 - Neuroscientific Data Analytics and AI (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5254},
      typ          = {PUB:(DE-HGF)25},
      eprint       = {2108.13481},
      howpublished = {arXiv:2108.13481},
      archivePrefix = {arXiv},
      SLACcitation = {$\%\%CITATION$ = $arXiv:2108.13481;\%\%$},
      url          = {https://juser.fz-juelich.de/record/897096},
}