TY  - JOUR
AU  - Fehlbaum, Lynn V
AU  - Borbás, Réka
AU  - Paul, Katharina
AU  - Eickhoff, Simon b
AU  - Raschle, Nora
TI  - Early and late neural correlates of mentalizing: ALE meta-analyses in adults, children and adolescents
JO  - Social cognitive and affective neuroscience
VL  - 17
IS  - 4
SN  - 1749-5024
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2021-03656
SP  - 351-366
PY  - 2022
AB  - The ability to understand mental states of others is referred to as mentalizing and enabled by our Theory of Mind. This social skill relies on brain regions comprising the mentalizing network, as robustly observed in adults, but also in a growing number of developmental studies. We summarized and compared neuroimaging evidence in children/adolescents and adults during mentalizing using coordinate-based activation likelihood estimation meta-analyses to inform about brain regions consistently or differentially engaged across age categories. Adults (N = 5286) recruited medial prefrontal and middle/inferior frontal cortices, precuneus, temporoparietal junction and middle temporal gyri during mentalizing, which were functionally connected to bilateral inferior/superior parietal lobule and thalamus/striatum. Conjunction and contrast analyses revealed that children and adolescents (N = 479) recruit similar, but fewer regions within core mentalizing regions. Subgroup analyses revealed an early continuous engagement of middle medial prefrontal cortex, precuneus and right temporoparietal junction in younger children (8-11y) and adolescents (12-18y). Adolescents additionally recruited the left temporoparietal junction and middle/inferior temporal cortex. Overall, the observed engagement of the medial prefrontal cortex, precuneus and right temporoparietal junction during mentalizing across all ages reflects an early specialization of some key regions of the social brain.
LB  - PUB:(DE-HGF)16
C6  - pmid:34545389
UR  - <Go to ISI:>//WOS:000776757400001
DO  - DOI:10.1093/scan/nsab105
UR  - https://juser.fz-juelich.de/record/897166
ER  -