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@ARTICLE{Snderby:897223,
      author       = {Sønderby, Ida E. and Ching, Christopher RK and
                      Thomopoulos, Sophia I and van der Meer, Dennis and
                      Villalon-Reina, Julio E. and Agartz, Ingrid and Amunts,
                      Katrin and Arango, Celso and Armstrong, Nicola J and
                      Ayesa-Arriola, Rosa and Bakker, Geor and Bassett, Anne S and
                      Boomsma, Dorret and Bülow, Robin and Butcher, Nancy J. and
                      Calhoun, Vince D and Caspers, Svenja and Chow, Eva WC and
                      Cichon, Sven and Ciufolini, Simone and Craig, Michael and
                      Crespo-Facorro, Benedicto and Cunningham, Adam and Dale,
                      Anders M and Dazzan, Paola and de Zubicaray, Greig Ian and
                      Djurovic, Srdjan and Doherty, Joanne L and Donohoe, Gary and
                      Draganski, Bogdan and Durdle, Courtney and Ehrlich, Stefan
                      and Emanuel, Beverly S and Espeseth, Thomas and Fisher,
                      Simon and Gan, Tian and Glahn, David C. and Grabe, Hans J.
                      and Gur, Raquel E. and Gutman, Boris A and Haakvik, Jan and
                      Håberg, Asta and Hansen, Laura A and Hashimoto, Ryota and
                      Hibar, Derrek P. and Holmes, Avram J and Hottenga, Jouke-Jan
                      and Pol, Hilleke E. Hulshoff and Jalbrzikowski, Maria and
                      Knowles, Emma EM and Kushan, Leila and Linden, David and
                      Lundervold, Astri J. and Martin-Brevet, Sandra and
                      Martínez, Kenia and Mather, Karen A and Mathias, Samuel R.
                      and McDonald-McGinn, Donna M and McRae, Allan F and Medland,
                      Sarah and Moberget, Torgeir and Modenato, Claudia and
                      Sánchez, Jennifer Monereo and Moreau, Clara and Mühleisen,
                      Thomas W and Paus, Tomáš and Pausova, Zdenka and Prieto,
                      Carlos and Ragothaman, Anjanibhargavi and Reinbold, Céline
                      S and Marques, Tiago Reis and Repetto, Gabriela M and
                      Reymond, Alexandre and Roalf, David R and
                      Rodriguez-Herreros, Borja and Rucker, James J and Sachdev,
                      Perminder S and Schmitt, James E and Schofield, Peter R and
                      Silva, Ana I and Stefansson, Hreinn and Stein, Dan J. and
                      Sun, Daqiang and Tamnes, Christian K. and
                      Tordesillas-Gutiérrez, Diana and Ulfarsson, Magnus O and
                      Vajdi, Ariana and van 't Ent, Dennis and van den Bree,
                      Marianne BM and Vázquez-Bourgon, Javier and Vila-Rodriguez,
                      fidel and Walters, G. Bragi and Wen, Wei and Westlye, Lars
                      T. and Wittfeld, Katharina and Zackai, Elaine H and
                      Stefánsson, Kári and Jacquemont, Sebastien and Thompson,
                      Paul and Bearden, Carrie E. and Andreassen, Ole A.},
      title        = {{E}ffects of copy number variations on brain structure and
                      risk for psychiatric illness: {L}arge-scale studies from the
                      {ENIGMA} {W}orking {G}roups on {CNV}s},
      journal      = {Human brain mapping},
      volume       = {43},
      number       = {1},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2021-03685},
      pages        = {300-328},
      year         = {2021},
      abstract     = {The Enhancing Neuroimaging Genetics through Meta-Analysis
                      copy number variant (ENIGMA-CNV) and 22q11.2 Deletion
                      Syndrome Working Groups (22q-ENIGMA WGs) were created to
                      gain insight into the involvement of genetic factors in
                      human brain development and related cognitive, psychiatric
                      and behavioral manifestations. To that end, the ENIGMA-CNV
                      WG has collated CNV and magnetic resonance imaging (MRI)
                      data from ~49,000 individuals across 38 global research
                      sites, yielding one of the largest studies to date on the
                      effects of CNVs on brain structures in the general
                      population. The 22q-ENIGMA WG includes 12 international
                      research centers that assessed over 533 individuals with a
                      confirmed 22q11.2 deletion syndrome, 40 with 22q11.2
                      duplications, and 333 typically developing controls,
                      creating the largest-ever 22q11.2 CNV neuroimaging data set.
                      In this review, we outline the ENIGMA infrastructure and
                      procedures for multi-site analysis of CNVs and MRI data. So
                      far, ENIGMA has identified effects of the 22q11.2, 16p11.2
                      distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and
                      cortical brain structures. Each CNV is associated with
                      differences in cognitive, neurodevelopmental and
                      neuropsychiatric traits, with characteristic patterns of
                      brain structural abnormalities. Evidence of gene-dosage
                      effects on distinct brain regions also emerged, providing
                      further insight into genotype-phenotype relationships. Taken
                      together, these results offer a more comprehensive picture
                      of molecular mechanisms involved in typical and atypical
                      brain development. This ‘genotype-first’ approach also
                      contributes to our understanding of the etiopathogenesis of
                      brain disorders. Finally, we outline future directions to
                      better understand effects of CNVs on brain structure and
                      behavior.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33615640},
      UT           = {WOS:000620229500001},
      doi          = {10.1002/hbm.25354},
      url          = {https://juser.fz-juelich.de/record/897223},
}