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@ARTICLE{Fricke:897395,
      author       = {Fricke, Philipp Moritz and Klemm, Angelika and Bott,
                      Michael and Polen, Tino},
      title        = {{O}n the way toward regulatable expression systems in
                      acetic acid bacteria: target gene expression and use cases},
      journal      = {Applied microbiology and biotechnology},
      volume       = {105},
      number       = {9},
      issn         = {1432-0614},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {FZJ-2021-03761},
      pages        = {3423 - 3456},
      year         = {2021},
      note         = {Biotechnologie 1},
      abstract     = {Acetic acid bacteria (AAB) are valuable biocatalysts for
                      which there is growing interest in understanding their
                      basics including physiology and biochemistry. This is
                      accompanied by growing demands for metabolic engineering of
                      AAB to take advantage of their properties and to improve
                      their biomanufacturing efficiencies. Controlled expression
                      of target genes is key to fundamental and applied
                      microbiological research. In order to get an overview of
                      expression systems and their applications in AAB, we carried
                      out a comprehensive literature search using the Web of
                      Science Core Collection database. The Acetobacteraceae
                      family currently comprises 49 genera. We found overall 6097
                      publications related to one or more AAB genera since 1973,
                      when the first successful recombinant DNA experiments in
                      Escherichia coli have been published. The use of plasmids in
                      AAB began in 1985 and till today was reported for only nine
                      out of the 49 AAB genera currently described. We found at
                      least five major expression plasmid lineages and a multitude
                      of further expression plasmids, almost all enabling only
                      constitutive target gene expression. Only recently, two
                      regulatable expression systems became available for AAB, an
                      N-acyl homoserine lactone (AHL)-inducible system for
                      Komagataeibacter rhaeticus and an l-arabinose-inducible
                      system for Gluconobacter oxydans. Thus, after 35 years of
                      constitutive target gene expression in AAB, we now have the
                      first regulatable expression systems for AAB in hand and
                      further regulatable expression systems for AAB can be
                      expected.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33856535},
      UT           = {WOS:000640472900002},
      doi          = {10.1007/s00253-021-11269-z},
      url          = {https://juser.fz-juelich.de/record/897395},
}