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@ARTICLE{Grigoriev:901807,
author = {Grigoriev, S. V. and Iashina, E. G. and Wu, Baohu and
Pipich, V. and Lang, Ch. and Radulescu, Aurel and
Bairamukov, V. Yu. and Filatov, M. V. and Pantina, R. A. and
Varfolomeeva, E. Yu.},
title = {{O}bservation of nucleic acid and protein correlation in
chromatin of {H}e{L}a nuclei using small-angle neutron
scattering with {D} 2 {O} − {H} 2 {O} contrast variation},
journal = {Physical review / E},
volume = {104},
number = {4},
issn = {2470-0053},
address = {Woodbury, NY},
publisher = {Inst.},
reportid = {FZJ-2021-03831},
pages = {044404},
year = {2021},
abstract = {The small-angle neutron scattering (SANS) on HeLa nuclei
demonstrates the bifractal nature of the chromatin
structural organization. The border line between two fractal
structures is detected as a crossover point at
Qc≈4×10−2nm−1 in the momentum transfer dependence
Q−D. The use of contrast variation (D2O−H2O) in SANS
measurements reveals clear similarity in the large scale
structural organizations of nucleic acids (NA) and proteins.
Both NA and protein structures have a mass fractal
arrangement with the fractal dimension of D≈2.5 at scales
smaller than 150 nm down to 20 nm. Both NA and proteins show
a logarithmic fractal behavior with D≈3 at scales larger
than 150 nm up to 6000 nm. The combined analysis of the SANS
and atomic force microscopy data allows one to conclude that
chromatin and its constitutes (DNA and proteins) are
characterized as soft, densely packed, logarithmic fractals
on the large scale and as rigid, loosely packed, mass
fractals on the smaller scale. The comparison of the partial
cross sections from NA and proteins with one from chromatin
as a whole demonstrates spatial correlation of two
chromatin's components in the range up to 900 nm. Thus
chromatin in HeLa nuclei is built as the unified structure
of the NA and proteins entwined through each other.
Correlation between two components is lost upon scale
increases toward 6000 nm. The structural features at the
large scale, probably, provide nuclei with the flexibility
and chromatin-free space to build supercorrelations on the
distance of 103 nm resembling cycle cell activity, such as
an appearance of nucleoli and a DNA replication.},
cin = {JCNS-FRM-II / JCNS-1 / JCNS-4 / MLZ},
ddc = {530},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-4-20201012 /
I:(DE-588b)4597118-3},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
(POF4-6G4) / 632 - Materials – Quantum, Complex and
Functional Materials (POF4-632)},
pid = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632},
experiment = {EXP:(DE-MLZ)KWS2-20140101 / EXP:(DE-MLZ)KWS3-20140101},
typ = {PUB:(DE-HGF)16},
pubmed = {34781557},
UT = {WOS:000706513200004},
doi = {10.1103/PhysRevE.104.044404},
url = {https://juser.fz-juelich.de/record/901807},
}