TY  - JOUR
AU  - Schedlich-Teufer, Charlotte
AU  - Jost, Stefanie Theresa
AU  - Krack, Paul
AU  - Witt, Karsten
AU  - Weintraub, Daniel
AU  - Baldermann, Juan Carlos
AU  - Sommerauer, Michael
AU  - Amstutz, Deborah
AU  - van Eimeren, Thilo
AU  - Dafsari, Haidar Salimi
AU  - Kalbe, Elke
AU  - Visser-Vandewalle, Veerle
AU  - Fink, Gereon Rudolf
AU  - Kessler, Josef
AU  - Barbe, Michael Thomas
TI  - Assessment of Affective-Behavioral States in Parkinson’s Disease Patients: Towards a New Screening Tool
JO  - Journal of Parkinson's Disease
VL  - 11
IS  - 3
SN  - 1877-718X
CY  - Amsterdam
PB  - IOS Press
M1  - FZJ-2021-03859
SP  - 1417 - 1430
PY  - 2021
AB  - Background:Assessment of affective-behavioral states in patients with Parkinson’s disease (PD) undergoing deep brain stimulation (DBS) is essential.Objective:To analyze well-established questionnaires as a pilot-study with the long term aim to develop a screening tool evaluating affective-behavioral dysfunction, including depression, anxiety, apathy, mania, and impulse control disorders, in PD patients screened for DBS.Methods:Two hundred ninety-seven inpatients with PD underwent standardized neuropsychiatric testing including German versions of Beck Depression Inventory-II, Hospital Anxiety and Depression Scale, Apathy Evaluation Scale, Self-Report Manic Inventory, and Questionnaire for Impulsive-Compulsive Disorders in PD-Rating Scale, to assess appropriateness for DBS. Statistical item reduction was based on exploratory factor analysis, Cronbach’s alpha, item-total correlations, item difficulty, and inter-item correlations. Confirmatory factor analysis was conducted to assess factorial validity. An expert rating was performed to identify clinically relevant items in the context of PD and DBS, to maintain content validity. We compared the shortened subscales with the original questionnaires using correlations. To determine cutoff points, receiver operating characteristics analysis was performed.Results:The items of the initial questionnaires were reduced from 129 to 38 items. Results of confirmatory factor analyses supported the validity of the shortened pool. It demonstrated high internal consistency (Cronbach’s alpha = 0.72–0.83 across subscales), and the individual subscales were correlated with the corresponding original scales (rs = 0.84–0.95). Sensitivities and specificities exceeded 0.7.
LB  - PUB:(DE-HGF)16
C6  - pmid:33967055
UR  - <Go to ISI:>//WOS:000683027900041
DO  - DOI:10.3233/JPD-202375
UR  - https://juser.fz-juelich.de/record/901838
ER  -