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@ARTICLE{SchedlichTeufer:901838,
author = {Schedlich-Teufer, Charlotte and Jost, Stefanie Theresa and
Krack, Paul and Witt, Karsten and Weintraub, Daniel and
Baldermann, Juan Carlos and Sommerauer, Michael and Amstutz,
Deborah and van Eimeren, Thilo and Dafsari, Haidar Salimi
and Kalbe, Elke and Visser-Vandewalle, Veerle and Fink,
Gereon Rudolf and Kessler, Josef and Barbe, Michael Thomas},
title = {{A}ssessment of {A}ffective-{B}ehavioral {S}tates in
{P}arkinson’s {D}isease {P}atients: {T}owards a {N}ew
{S}creening {T}ool},
journal = {Journal of Parkinson's Disease},
volume = {11},
number = {3},
issn = {1877-718X},
address = {Amsterdam},
publisher = {IOS Press},
reportid = {FZJ-2021-03859},
pages = {1417 - 1430},
year = {2021},
abstract = {Background:Assessment of affective-behavioral states in
patients with Parkinson’s disease (PD) undergoing deep
brain stimulation (DBS) is essential.Objective:To analyze
well-established questionnaires as a pilot-study with the
long term aim to develop a screening tool evaluating
affective-behavioral dysfunction, including depression,
anxiety, apathy, mania, and impulse control disorders, in PD
patients screened for DBS.Methods:Two hundred ninety-seven
inpatients with PD underwent standardized neuropsychiatric
testing including German versions of Beck Depression
Inventory-II, Hospital Anxiety and Depression Scale, Apathy
Evaluation Scale, Self-Report Manic Inventory, and
Questionnaire for Impulsive-Compulsive Disorders in
PD-Rating Scale, to assess appropriateness for DBS.
Statistical item reduction was based on exploratory factor
analysis, Cronbach’s alpha, item-total correlations, item
difficulty, and inter-item correlations. Confirmatory factor
analysis was conducted to assess factorial validity. An
expert rating was performed to identify clinically relevant
items in the context of PD and DBS, to maintain content
validity. We compared the shortened subscales with the
original questionnaires using correlations. To determine
cutoff points, receiver operating characteristics analysis
was performed.Results:The items of the initial
questionnaires were reduced from 129 to 38 items. Results of
confirmatory factor analyses supported the validity of the
shortened pool. It demonstrated high internal consistency
(Cronbach’s alpha = 0.72–0.83 across subscales), and
the individual subscales were correlated with the
corresponding original scales (rs = 0.84–0.95).
Sensitivities and specificities exceeded 0.7.},
cin = {INM-3},
ddc = {610},
cid = {I:(DE-Juel1)INM-3-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:33967055},
UT = {WOS:000683027900041},
doi = {10.3233/JPD-202375},
url = {https://juser.fz-juelich.de/record/901838},
}