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@ARTICLE{Kleineberg:901854,
      author       = {Kleineberg, Nina N. and Knauss, Samuel and Gülke, Eileen
                      and Pinnschmidt, Hans O. and Jakob, Carolin E. M. and
                      Lingor, Paul and Hellwig, Kerstin and Berthele, Achim and
                      Höglinger, Günter and Fink, Gereon R. and Endres, Matthias
                      and Gerloff, Christian and Klein, Christine and Stecher,
                      Melanie and Classen, Annika Y. and Rieg, Siegbert and
                      Borgmann, Stefan and Hanses, Frank and Rüthrich, Maria M.
                      and Hower, Martin and Tometten, Lukas and Haselberger,
                      Martina and Piepel, Christiane and Merle, Uta and Dolff,
                      Sebastian and Degenhardt, Christian and Jensen, Björn-Erik
                      O. and Vehreschild, Maria J. G. T. and Erber, Johanna and
                      Franke, Christiana and Warnke, Clemens},
      title        = {{N}eurological symptoms and complications in predominantly
                      hospitalized {COVID}‐19 patients: {R}esults of the
                      {E}uropean multinational {L}ean {E}uropean {O}pen {S}urvey
                      on {SARS}‐{I}nfected {P}atients ({LEOSS})},
      journal      = {European journal of neurology},
      volume       = {28},
      number       = {12},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science},
      reportid     = {FZJ-2021-03869},
      pages        = {3925-3937},
      year         = {2021},
      abstract     = {Background and purposeDuring acute coronavirus disease 2019
                      (COVID-19) infection, neurological signs, symptoms and
                      complications occur. We aimed to assess their clinical
                      relevance by evaluating real-world data from a multinational
                      registry.MethodsWe analyzed COVID-19 patients from 127
                      centers, diagnosed between January 2020 and February 2021,
                      and registered in the European multinational LEOSS (Lean
                      European Open Survey on SARS-Infected Patients) registry.
                      The effects of prior neurological diseases and the effect of
                      neurological symptoms on outcome were studied using
                      multivariate logistic regression.ResultsA total of 6537
                      COVID-19 patients $(97.7\%$ PCR-confirmed) were analyzed, of
                      whom $92.1\%$ were hospitalized and $14.7\%$ died. Commonly,
                      excessive tiredness $(28.0\%),$ headache $(18.5\%),$
                      nausea/emesis $(16.6\%),$ muscular weakness $(17.0\%),$
                      impaired sense of smell $(9.0\%)$ and taste $(12.8\%),$ and
                      delirium $(6.7\%)$ were reported. In patients with a
                      complicated or critical disease course $(53\%)$ the most
                      frequent neurological complications were ischemic stroke
                      $(1.0\%)$ and intracerebral bleeding (ICB; $2.2\%).$ ICB
                      peaked in the critical disease phase $(5\%)$ and was
                      associated with the administration of anticoagulation and
                      extracorporeal membrane oxygenation (ECMO). Excessive
                      tiredness (odds ratio [OR] 1.42, $95\%$ confidence interval
                      [CI] 1.20–1.68) and prior neurodegenerative diseases (OR
                      1.32, $95\%$ CI 1.07–1.63) were associated with an
                      increased risk of an unfavorable outcome. Prior
                      cerebrovascular and neuroimmunological diseases were not
                      associated with an unfavorable short-term outcome of
                      COVID-19.ConclusionOur data on mostly hospitalized COVID-19
                      patients show that excessive tiredness or prior
                      neurodegenerative disease at first presentation increase the
                      risk of an unfavorable short-term outcome. ICB in critical
                      COVID-19 was associated with therapeutic interventions, such
                      as anticoagulation and ECMO, and thus may be an indirect
                      complication of a life-threatening systemic viral
                      infection.},
      cin          = {INM-3 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34411383},
      UT           = {WOS:000692461300001},
      doi          = {10.1111/ene.15072},
      url          = {https://juser.fz-juelich.de/record/901854},
}