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000901975 1001_ $$0P:(DE-Juel1)145387$$aJütten, Kerstin$$b0$$eCorresponding author
000901975 245__ $$aDiffusion Tensor Imaging Reveals Microstructural Heterogeneity of Normal-Appearing White Matter and Related Cognitive Dysfunction in Glioma Patients
000901975 260__ $$aLausanne$$bFrontiers Media$$c2019
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000901975 520__ $$aImmunohistochemical data based on isocitrate–dehydrogenase (IDH) mutation status have redefined glioma as a whole-brain disease, while occult tumor cell invasion along white matter fibers is inapparent in conventional magnetic resonance imaging (MRI). The functional and prognostic impact of focal glioma may however relate to the extent of white matter involvement. We used diffusion tensor imaging (DTI) to investigate microstructural characteristics of whole-brain normal-appearing white matter (NAWM) in relation to cognitive functions as potential surrogates for occult white matter involvement in glioma. Twenty patients (12 IDH-mutated) and 20 individually matched controls were preoperatively examined using DTI combined with a standardized neuropsychological examination. Tumor lesions including perifocal edema were masked, and fractional anisotropy (FA) as well as mean, radial, and axial diffusivity (MD, RD, and AD, respectively) of the remaining whole-brain NAWM were determined by using Tract-Based Spatial Statistics and histogram analyses. The relationship between extratumoral white matter integrity and cognitive performance was examined using partial correlation analyses controlling for age, education, and lesion volumes. In patients, mean FA and AD were decreased as compared to controls, which agrees with the notion of microstructural impairment of NAWM in glioma patients. Patients performed worse in all cognitive domains tested, and higher anisotropy and lower MD and RD values of NAWM were associated with better cognitive performance. In additional analyses, IDH-mutated and IDH-wildtype patients were compared. Patients with IDH-mutation showed higher FA, but lower MD, AD, and RD values as compared to IDH-wildtype patients, suggesting a better preserved microstructural integrity of NAWM, which may relate to a less infiltrative nature of IDH-mutated gliomas. Diffusion-based phenotyping and monitoring microstructural integrity of extratumoral whole-brain NAWM may aid in estimating occult white matter involvement and should be considered as a complementary biomarker in glioma.
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000901975 7001_ $$0P:(DE-HGF)0$$aMainz, Verena$$b1
000901975 7001_ $$0P:(DE-HGF)0$$aGauggel, Siegfried$$b2
000901975 7001_ $$0P:(DE-HGF)0$$aPatel, Harshal Jayeshkumar$$b3
000901975 7001_ $$0P:(DE-Juel1)142495$$aBinkofski, Ferdinand$$b4
000901975 7001_ $$0P:(DE-HGF)0$$aWiesmann, Martin$$b5
000901975 7001_ $$0P:(DE-HGF)0$$aClusmann, Hans$$b6
000901975 7001_ $$0P:(DE-HGF)0$$aNa, Chuh-Hyoun$$b7
000901975 773__ $$0PERI:(DE-600)2649216-7$$a10.3389/fonc.2019.00536$$gVol. 9, p. 536$$p536$$tFrontiers in oncology$$v9$$x2234-943X$$y2019
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