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000901976 1001_ $$0P:(DE-HGF)0$$aJauch-Chara, Kamila$$b0$$eCorresponding author
000901976 245__ $$aBlunted Brain Energy Consumption Relates to Insula Atrophy and Impaired Glucose Tolerance in Obesity
000901976 260__ $$aAlexandria, Va$$bAssoc.$$c2015
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000901976 520__ $$aBrain energy consumption induced by electrical stimulation increases systemic glucose tolerance in normal-weight men. In obesity, fundamental reductions in brain energy levels, gray matter density, and cortical metabolism, as well as chronically impaired glucose tolerance, suggest that disturbed neuroenergetic regulation may be involved in the development of overweight and obesity. Here, we induced neuronal excitation by anodal transcranial direct current stimulation versus sham, examined cerebral energy consumption with 31P magnetic resonance spectroscopy, and determined systemic glucose uptake by euglycemic-hyperinsulinemic glucose clamp in 15 normal-weight and 15 obese participants. We demonstrate blunted brain energy consumption and impaired systemic glucose uptake in obese compared with normal-weight volunteers, indicating neuroenergetic dysregulation in obese humans. Broadening our understanding of reduced multifocal gray matter volumes in obesity, our findings show that reduced appetite- and taste-processing area morphometry is associated with decreased brain energy levels. Specifically, gray matter volumes of the insula relate to brain energy content in obese participants. Overall, our results imply that a diminished cerebral energy supply may underlie the decline in brain areas assigned to food intake regulation and therefore the development of obesity.
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000901976 7001_ $$0P:(DE-Juel1)142495$$aBinkofski, Ferdinand$$b1$$ufzj
000901976 7001_ $$0P:(DE-HGF)0$$aLoebig, Michaela$$b2
000901976 7001_ $$0P:(DE-Juel1)177889$$aReetz, Kathrin$$b3$$ufzj
000901976 7001_ $$0P:(DE-HGF)0$$aJahn, Gianna$$b4
000901976 7001_ $$0P:(DE-HGF)0$$aMelchert, Uwe H.$$b5
000901976 7001_ $$0P:(DE-HGF)0$$aSchweiger, Ulrich$$b6
000901976 7001_ $$0P:(DE-HGF)0$$aOltmanns, Kerstin M.$$b7
000901976 773__ $$0PERI:(DE-600)1501252-9$$a10.2337/db14-0421$$gVol. 64, no. 6, p. 2082 - 2091$$n6$$p2082 - 2091$$tDiabetes$$v64$$x1939-327X$$y2015
000901976 8564_ $$uhttps://juser.fz-juelich.de/record/901976/files/2082.full.pdf
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