% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{JauchChara:901976,
      author       = {Jauch-Chara, Kamila and Binkofski, Ferdinand and Loebig,
                      Michaela and Reetz, Kathrin and Jahn, Gianna and Melchert,
                      Uwe H. and Schweiger, Ulrich and Oltmanns, Kerstin M.},
      title        = {{B}lunted {B}rain {E}nergy {C}onsumption {R}elates to
                      {I}nsula {A}trophy and {I}mpaired {G}lucose {T}olerance in
                      {O}besity},
      journal      = {Diabetes},
      volume       = {64},
      number       = {6},
      issn         = {1939-327X},
      address      = {Alexandria, Va},
      publisher    = {Assoc.},
      reportid     = {FZJ-2021-03950},
      pages        = {2082 - 2091},
      year         = {2015},
      abstract     = {Brain energy consumption induced by electrical stimulation
                      increases systemic glucose tolerance in normal-weight men.
                      In obesity, fundamental reductions in brain energy levels,
                      gray matter density, and cortical metabolism, as well as
                      chronically impaired glucose tolerance, suggest that
                      disturbed neuroenergetic regulation may be involved in the
                      development of overweight and obesity. Here, we induced
                      neuronal excitation by anodal transcranial direct current
                      stimulation versus sham, examined cerebral energy
                      consumption with 31P magnetic resonance spectroscopy, and
                      determined systemic glucose uptake by
                      euglycemic-hyperinsulinemic glucose clamp in 15
                      normal-weight and 15 obese participants. We demonstrate
                      blunted brain energy consumption and impaired systemic
                      glucose uptake in obese compared with normal-weight
                      volunteers, indicating neuroenergetic dysregulation in obese
                      humans. Broadening our understanding of reduced multifocal
                      gray matter volumes in obesity, our findings show that
                      reduced appetite- and taste-processing area morphometry is
                      associated with decreased brain energy levels. Specifically,
                      gray matter volumes of the insula relate to brain energy
                      content in obese participants. Overall, our results imply
                      that a diminished cerebral energy supply may underlie the
                      decline in brain areas assigned to food intake regulation
                      and therefore the development of obesity.},
      cin          = {INM-4 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25576052},
      UT           = {WOS:000355370900023},
      doi          = {10.2337/db14-0421},
      url          = {https://juser.fz-juelich.de/record/901976},
}