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@ARTICLE{Jost:902002,
      author       = {Jost, Stefanie T. and Ray Chaudhuri, K. and Ashkan,
                      Keyoumars and Loehrer, Philipp A. and Silverdale, Monty and
                      Rizos, Alexandra and Evans, Julian and Petry-Schmelzer, Jan
                      Niklas and Barbe, Michael T. and Sauerbier, Anna and Fink,
                      Gereon R. and Visser-Vandewalle, Veerle and Antonini, Angelo
                      and Martinez-Martin, Pablo and Timmermann, Lars and Dafsari,
                      Haidar S.},
      title        = {{S}ubthalamic {S}timulation {I}mproves {Q}uality of {S}leep
                      in {P}arkinson {D}isease: {A} 36-{M}onth {C}ontrolled
                      {S}tudy},
      journal      = {Journal of Parkinson's Disease},
      volume       = {11},
      number       = {1},
      issn         = {1877-718X},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {FZJ-2021-03965},
      pages        = {323 - 335},
      year         = {2021},
      abstract     = {Background:Sleep disturbances and neuropsychiatric symptoms
                      are some of the most common nonmotor symptoms in
                      Parkinson’s disease (PD). The effect of subthalamic
                      stimulation (STN-DBS) on these symptoms beyond a short-term
                      follow-up is unclear.Objective:To examine 36-month effects
                      of bilateral STN-DBS on quality of sleep, depression,
                      anxiety, and quality of life (QoL) compared to
                      standard-of-care medical therapy (MED) in PD.Methods:In this
                      prospective, controlled, observational, propensity score
                      matched, international multicenter study, we assessed sleep
                      disturbances using the PDSleep Scale-1 (PDSS), QoL employing
                      the PDQuestionnaire-8 (PDQ-8), motor disorder with the
                      Scales for Outcomes in PD (SCOPA), anxiety and depression
                      with the Hospital Anxiety and Depression Scale (HADS), and
                      dopaminergic medication requirements (LEDD). Within-group
                      longitudinal outcome changes were tested using Wilcoxon
                      signed-rank and between-group longitudinal differences of
                      change scores with Mann-Whitney U tests. Spearman
                      correlations analyzed the relationships of outcome parameter
                      changes at follow-up.Results:Propensity score matching
                      applied on 159 patients (STN-DBS n = 75, MED n = 84)
                      resulted in 40 patients in each treatment group. At 36-month
                      follow-up, STN-DBS led to significantly better PDSS and
                      PDQ-8 change scores, which were significantly correlated. We
                      observed no significant effects for HADS and no significant
                      correlations between change scores in PDSS, HADS, and
                      LEDD.Conclusions:We report Class IIb evidence of beneficial
                      effects of STN-DBS on quality of sleep at 36-month
                      follow-up, which were associated with QoL improvement
                      independent of depression and dopaminergic medication. Our
                      study highlights the importance of sleep for assessments of
                      DBS outcomes.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33074192},
      UT           = {WOS:000618063800028},
      doi          = {10.3233/JPD-202278},
      url          = {https://juser.fz-juelich.de/record/902002},
}