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@ARTICLE{Rosen:902026,
      author       = {Rosen, Jurij and Stoffels, Gabriele and Lohmann, Philipp
                      and Bauer, Elena K. and Werner, Jan-Michael and Wollring,
                      Michael and Rapp, Marion and Felsberg, Jörg and Kocher,
                      Martin and Fink, Gereon R. and Langen, Karl-Josef and
                      Galldiks, Norbert},
      title        = {{P}rognostic value of pre-irradiation {FET} {PET} in
                      patients with not completely resectable {IDH}-wildtype
                      glioma and minimal or absent contrast enhancement},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2021-03984},
      pages        = {20828},
      year         = {2021},
      abstract     = {In glioma patients, complete resection of the
                      contrast-enhancing portion is associated with improved
                      survival, which, however, cannot be achieved in a
                      considerable number of patients. Here, we evaluated the
                      prognostic value of O-(2-[18F]-fluoroethyl)-L-tyrosine (FET)
                      PET in not completely resectable glioma patients with
                      minimal or absent contrast enhancement before temozolomide
                      chemoradiation. Dynamic FET PET scans were performed in 18
                      newly diagnosed patients with partially resected (n = 8)
                      or biopsied (n = 10) IDH-wildtype astrocytic glioma
                      before initiation of temozolomide chemoradiation. Static and
                      dynamic FET PET parameters, as well as contrast-enhancing
                      volumes on MRI, were calculated. Using receiver operating
                      characteristic analyses, threshold values for which the
                      product of paired values for sensitivity and specificity
                      reached a maximum were obtained. Subsequently, the
                      prognostic values of FET PET parameters and
                      contrast-enhancing volumes on MRI were evaluated using
                      univariate Kaplan–Meier and multivariate Cox regression
                      (including the MTV, age, MGMT promoter methylation, and
                      contrast-enhancing volume) survival analyses for
                      progression-free and overall survival (PFS, OS). On MRI,
                      eight patients had no contrast enhancement; the remaining
                      patients had minimal contrast-enhancing volumes (range,
                      0.2–5.3 mL). Univariate analyses revealed that smaller
                      pre-irradiation FET PET tumor volumes were significantly
                      correlated with a more favorable PFS (7.9 vs. 4.2 months;
                      threshold, 14.8 mL; P = 0.012) and OS (16.6 vs. 9.0
                      months; threshold, 23.8 mL; P = 0.002). In contrast,
                      mean tumor-to-brain ratios and time-to-peak values were only
                      associated with a longer PFS (P = 0.048 and
                      P = 0.045, respectively). Furthermore, the
                      pre-irradiation FET PET tumor volume remained significant in
                      multivariate analyses (P = 0.043), indicating an
                      independent predictor for OS. Our results suggest that
                      pre-irradiation FET PET parameters have a prognostic impact
                      in this subgroup of patients.},
      cin          = {INM-3 / INM-4},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34675225},
      UT           = {WOS:000709931300019},
      doi          = {10.1038/s41598-021-00193-x},
      url          = {https://juser.fz-juelich.de/record/902026},
}