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@ARTICLE{Brcina:902029,
      author       = {Brcina, Nikolina and Hohenfeld, Christian and Heidbreder,
                      Anna and Mirzazade, Shahram and Krahe, Janna and Wojtala,
                      Jennifer and Binkofski, Ferdinand and Schulz, Jörg B. and
                      Schiefer, Johannes and Reetz, Kathrin and Dogan, Imis},
      title        = {{I}ncreased neural motor activation and functional
                      reorganization in patients with idiopathic rapid eye
                      movement sleep behavior disorder},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {92},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-03987},
      pages        = {76-82},
      year         = {2021},
      abstract     = {IntroductionAltered brain activity and functional
                      reorganization patterns during self-initiated movements have
                      been reported in early pre-motor and motor stages of
                      Parkinson's disease. The aim of this study was to
                      investigate whether similar alterations can be observed in
                      patients with idiopathic REM-sleep behavior disorder
                      (RBD).Methods13 polysomnography-confirmed male and
                      right-handed RBD patients and 13 healthy controls underwent
                      a bilateral hand-movement fMRI task including internally
                      selected (INT) and externally-guided (EXT) movement
                      conditions for each hand. We examined functional activity
                      and connectivity differences between groups and
                      task-conditions, structural differences using voxel-based
                      morphometry, as well as associations between functional
                      activity and clinical variables.ResultsNo group differences
                      were observed in fMRI-task performance or in voxel-based
                      morphometry. Both groups showed faster reaction times and
                      exhibited greater neural activation when movements were
                      internally selected compared to externally-guided tasks.
                      Compared to controls, RBD patients displayed stronger
                      activation in the dorsolateral prefrontal cortex and primary
                      somatosensory cortex during INT-tasks, and in the right
                      fronto-insular cortex during EXT-tasks performed with the
                      non-dominant hand. Stronger activation in RBD patients was
                      associated with cognitive and olfactory impairment.
                      Connectivity analysis demonstrated overall less
                      interregional coupling in patients compared to controls. In
                      particular, patients showed reduced temporo-cerebellar,
                      occipito-cerebellar and intra-cerebellar connectivity, but
                      stronger connectivity in fronto-cerebellar and
                      fronto-occipital pathways.ConclusionThe observed stronger
                      activation during hand-movement tasks and connectivity
                      changes in RBD may reflect early compensatory and
                      reorganization patterns in order to preserve motor
                      functioning. Our findings may contribute to a better
                      understanding and prognosis of prodromal stages of
                      α-synucleinopathies.},
      cin          = {INM-4 / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34715608},
      UT           = {WOS:000717972300001},
      doi          = {10.1016/j.parkreldis.2021.10.019},
      url          = {https://juser.fz-juelich.de/record/902029},
}