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000902074 0247_ $$2ISSN$$a1619-7089
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000902074 1001_ $$0P:(DE-HGF)0$$aSong, Mengmeng$$b0
000902074 245__ $$aFeasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy
000902074 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2021
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000902074 520__ $$aPurposeDynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [18F]PI-2620 tau-PET imaging of PSP.MethodsThirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [18F]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0–60, 0–50, 0–40, 0–30, and 0–20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20–40, 30–50, and 40–60 min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier).Results0–50 and 0–40 DVR showed equivalent effect sizes as 0–60 DVR (averaged Cohen’s d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0–30 or 0–20 DVR. The 20–40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen’s d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0–60 DVR (AUC: 0.96), 0–40 DVR (AUC: 0.96), and 20–40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%.ConclusionTruncated and static imaging windows can be used for [18F]PI-2620 PET imaging of PSP. 0–40 min dynamic scanning offers the best balance between accuracy and economic scanning.
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000902074 7001_ $$0P:(DE-HGF)0$$aScheifele, Maximilian$$b1
000902074 7001_ $$0P:(DE-HGF)0$$aBarthel, Henryk$$b2
000902074 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b3
000902074 7001_ $$0P:(DE-HGF)0$$aBeyer, Leonie$$b4
000902074 7001_ $$0P:(DE-HGF)0$$aMarek, Ken$$b5
000902074 7001_ $$0P:(DE-HGF)0$$aEckenweber, Florian$$b6
000902074 7001_ $$0P:(DE-HGF)0$$aPalleis, Carla$$b7
000902074 7001_ $$0P:(DE-HGF)0$$aKaiser, Lena$$b8
000902074 7001_ $$0P:(DE-HGF)0$$aFinze, Anika$$b9
000902074 7001_ $$0P:(DE-HGF)0$$aKern, Maike$$b10
000902074 7001_ $$0P:(DE-HGF)0$$aNitschmann, Alexander$$b11
000902074 7001_ $$0P:(DE-HGF)0$$aBiechele, Gloria$$b12
000902074 7001_ $$0P:(DE-HGF)0$$aKatzdobler, Sabrina$$b13
000902074 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gèrard$$b14$$ufzj
000902074 7001_ $$0P:(DE-Juel1)184744$$aHammes, Jochen$$b15$$ufzj
000902074 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b16
000902074 7001_ $$0P:(DE-HGF)0$$aSaur, Dorothee$$b17
000902074 7001_ $$0P:(DE-HGF)0$$aSchroeter, Matthias L.$$b18
000902074 7001_ $$0P:(DE-HGF)0$$aRumpf, Jost-Julian$$b19
000902074 7001_ $$0P:(DE-HGF)0$$aRullmann, Michael$$b20
000902074 7001_ $$0P:(DE-HGF)0$$aSchildan, Andreas$$b21
000902074 7001_ $$0P:(DE-HGF)0$$aPatt, Marianne$$b22
000902074 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b23$$ufzj
000902074 7001_ $$0P:(DE-HGF)0$$aStephens, Andrew W.$$b24
000902074 7001_ $$0P:(DE-HGF)0$$aRauchmann, Boris-Stephan$$b25
000902074 7001_ $$0P:(DE-HGF)0$$aPerneczky, Robert$$b26
000902074 7001_ $$0P:(DE-HGF)0$$aLevin, Johannes$$b27
000902074 7001_ $$0P:(DE-HGF)0$$aClassen, Joseph$$b28
000902074 7001_ $$0P:(DE-HGF)0$$aHöglinger, Günter U.$$b29
000902074 7001_ $$0P:(DE-HGF)0$$aBartenstein, Peter$$b30
000902074 7001_ $$0P:(DE-HGF)0$$aBoening, Guido$$b31
000902074 7001_ $$0P:(DE-HGF)0$$aZiegler, Sibylle$$b32
000902074 7001_ $$0P:(DE-HGF)0$$aVillemagne, Victor$$b33
000902074 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b34$$ufzj
000902074 7001_ $$0P:(DE-HGF)0$$aSeibyl, John$$b35
000902074 7001_ $$0P:(DE-HGF)0$$aSabri, Osama$$b36
000902074 7001_ $$00000-0002-9247-2843$$aBrendel, Matthias$$b37$$eCorresponding author
000902074 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-021-05391-3$$gVol. 48, no. 12, p. 3872 - 3885$$n12$$p3872 - 3885$$tEuropean journal of nuclear medicine and molecular imaging$$v48$$x1619-7089$$y2021
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